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Details on Person UniProt:P36957 DLST
| Class:Id | ReferenceGeneProduct:60870 |
|---|---|
| _chainChangeLog | transit peptide:1-67 added on Fri February 6 2015;chain:68-453 added on Fri February 6 2015 |
| _displayName | UniProt:P36957 DLST |
| _timestamp | 2025-05-21 21:57:13 |
| chain | transit peptide:1-67 chain:68-453 |
| checksum | A30E8CC959106B8F |
| comment | FUNCTION Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711, PubMed:30929736). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).CATALYTIC ACTIVITY N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + succinyl-CoA = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CoACOFACTOR Binds 1 lipoyl cofactor covalently.PATHWAY Amino-acid degradation; L-lysine degradation via saccharopine pathway; glutaryl-CoA from L-lysine: step 6/6.PATHWAY Carbohydrate metabolism; tricarboxylic acid cycle.SUBUNIT The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2), DLD (dihydrolipoamide dehydrogenase; E3) and the assembly factor KGD4 (By similarity). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A (PubMed:29211711). Interacts with ABHD11; this interaction maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (PubMed:32792488).INTERACTION Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.ALTERNATIVE PRODUCTS Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the 2-oxoacid dehydrogenase family. |
| description | recommendedName: fullName evidence="13"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial ecNumber evidence="8"2.3.1.61 alternativeName: 2-oxoglutarate dehydrogenase complex component E2 shortName: OGDC-E2 alternativeName: Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex alternativeName: E2K |
| geneName | DLST DLTS |
| identifier | P36957 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Acyltransferase Alternative splicing Direct protein sequencing Disease variant Lipoyl Mitochondrion Nucleus Phosphoprotein Proteomics identification Reference proteome Transferase Transit peptide Tricarboxylic acid cycle |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 |
| name | DLST |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994398] ENSEMBL:ENSG00000119689 DLST [Homo sapiens] |
| secondaryIdentifier | ODO2_HUMAN B7Z5W8 E7ESY5 Q7LDY7 Q9BQ32 |
| sequenceLength | 453 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976133] UniProt:P36957-1 DLST [Homo sapiens] [ReferenceIsoform:8976134] UniProt:P36957-2 DLST [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:69993] Lipo-K110-DLST [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:6792574] DLST [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9853485] LipoH2-K110-DLST [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9853502] SuccinyllipoH2-K110-DLST [mitochondrial matrix] [Homo sapiens] [EntityWithAccessionedSequence:9858581] GlutaryllipoH2-K110-DLST [mitochondrial matrix] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:508501] N6-lipoyl-L-lysine at 110 [GroupModifiedResidue:9853495] N6-lipoyl-L-lysine ((R)-N6-(S8-succinyldihydrolipoyl)-L-lysine residue) at 110 [GroupModifiedResidue:9853515] N6-lipoyl-L-lysine ((R)-N6-dihydrolipoyl-L-lysine residue) at 110 [GroupModifiedResidue:9858578] N6-lipoyl-L-lysine ((R)-N6-(S8-glutaryldihydrolipoyl)-L-lysine(1−) residue) at 110 |
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No pathways have been reviewed or authored by UniProt:P36957 DLST (60870)
