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Details on Person UniProt:Q02218 OGDH
| Class:Id | ReferenceGeneProduct:60868 |
|---|---|
| _chainChangeLog | transit peptide:1-40 added on Fri February 6 2015;chain:41-1023 added on Fri February 6 2015 |
| _displayName | UniProt:Q02218 OGDH |
| _timestamp | 2026-02-20 23:08:47 |
| chain | transit peptide:1-40 chain:41-1023 |
| checksum | F428DD342F232E7C |
| comment | FUNCTION 2-oxoglutarate dehydrogenase (E1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHC) (PubMed:24495017, PubMed:25210035, PubMed:28435050). Participates in the first step, rate limiting for the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) catalyzed by the whole OGDHC (PubMed:24495017, PubMed:25210035, PubMed:28435050). Catalyzes the irreversible decarboxylation of 2-oxoglutarate (alpha-ketoglutarate) via the thiamine diphosphate (ThDP) cofactor and subsequent transfer of the decarboxylated acyl intermediate on an oxidized dihydrolipoyl group that is covalently amidated to the E2 enzyme (dihydrolipoyllysine-residue succinyltransferase or DLST) (PubMed:24495017, PubMed:25210035, PubMed:28435050, PubMed:35272141). Plays a key role in the Krebs (citric acid) cycle, which is a common pathway for oxidation of fuel molecules, including carbohydrates, fatty acids, and amino acids (PubMed:25210035). Can catalyze the decarboxylation of 2-oxoadipate in vitro, but at a much lower rate than 2-oxoglutarate (PubMed:28435050). Can also convert 2-keto-4-hydroxyglutarate (KHG) and CoA into malyl-CoA (By similarity). Mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711).CATALYTIC ACTIVITY N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 2-oxoglutarate + H(+) = N(6)-[(R)-S(8)-succinyldihydrolipoyl]-L-lysyl-[protein] + CO2COFACTOR Calcium ions and ADP stimulate, whereas ATP and NADH reduce catalytic activity.BIOPHYSICOCHEMICAL PROPERTIES Optimum temperature is 37 degrees Celsius. Activity decreases with increasing temperature.SUBUNIT Homodimer (PubMed:35272141). The 2-oxoglutarate dehydrogenase complex is composed of OGDH (2-oxoglutarate dehydrogenase; E1), DLST (dihydrolipoamide succinyltransferase; E2), DLD (dihydrolipoamide dehydrogenase; E3), and the assembly factor KGD4 (By similarity). It contains multiple copies of the three enzymatic components (E1, E2 and E3). In the nucleus, the 2-oxoglutarate dehydrogenase complex associates with KAT2A (PubMed:29211711). Interacts with ABHD11; this interaction maintains the functional lipoylation of the 2-oxoglutarate dehydrogenase complex (PubMed:32792488).INTERACTION Mainly localizes in the mitochondrion. A small fraction localizes to the nucleus, where the 2-oxoglutarate dehydrogenase complex is required for histone succinylation.ALTERNATIVE PRODUCTS Probably insensitive to calcium.MISCELLANEOUS The mitochondrial 2-oxoglutarate and 2-oxoadipate dehydrogenase complexes (OGDHC and OADHC, respectively) share their E2 (DLST) and E3 (dihydrolipoyl dehydrogenase or DLD) components, but the E1 component is specific to each complex (E1o and E1a (DHTK1), respectively).SIMILARITY Belongs to the alpha-ketoglutarate dehydrogenase family.SEQUENCE CAUTION Alpha-ketoglutarate dehydrogenase entry |
| description | recommendedName: fullName evidence="17"2-oxoglutarate dehydrogenase complex component E1 shortName: E1o shortName evidence="16"HsOGDH shortName: OGDC-E1 shortName: OGDH-E1 ecNumber evidence="7 8 9 10 12"1.2.4.2 alternativeName: 2-oxoglutarate dehydrogenase, mitochondrial alternativeName: Alpha-ketoglutarate dehydrogenase shortName: Alpha-KGDH-E1 alternativeName: Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase |
| geneName | OGDH |
| identifier | Q02218 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Calcium Glycolysis Isopeptide bond Magnesium Metal-binding Mitochondrion Nucleus Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Thiamine pyrophosphate Transit peptide Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | OGDH |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993194] ENSEMBL:ENSG00000105953 OGDH [Homo sapiens] |
| secondaryIdentifier | ODO1_HUMAN B4E2U9 D3DVL0 E9PBM1 Q96DD3 Q9UDX0 |
| sequenceLength | 1023 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977125] UniProt:Q02218-1 OGDH [Homo sapiens] [ReferenceIsoform:8977126] UniProt:Q02218-2 OGDH [Homo sapiens] [ReferenceIsoform:8977127] UniProt:Q02218-3 OGDH [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:69981] OGDH [mitochondrial matrix] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q02218 OGDH (60868)
