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Details on Person HJURP:CENPA complex localizes to the centromere

Class:Id	Reaction:606326
_displayName	HJURP:CENPA complex localizes to the centromere
_doRelease	TRUE
_timestamp	2014-11-02 09:35:37
authored	[InstanceEdit:599714] May, B, 2010-04-15
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:606312] May, B, 2010-04-17
edited	[InstanceEdit:599714] May, B, 2010-04-15
input	[Complex:606319] HJURP:NPM1:RBBP4:RBBP7:RUVBL1:CENPA:H4 [nucleoplasm] [Homo sapiens] [Complex:606342] CCAN:DNA:CASC5:Mis18 complex [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:606283] Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP [LiteratureReference:606307] HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeres [LiteratureReference:606290] HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres [LiteratureReference:606344] Priming of centromere for CENP-A recruitment by human hMis18alpha, hMis18beta, and M18BP1 [LiteratureReference:5633504] HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
modified	[InstanceEdit:772522] May, B, 2010-05-21 [InstanceEdit:847691] May, B, 2010-05-30 [InstanceEdit:877409] May, B, 2010-06-14 [InstanceEdit:877423] May, B, 2010-06-14 [InstanceEdit:5252141] May, B, 2014-02-05 [InstanceEdit:5633525] May, Bruce, 2014-11-02 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	HJURP:CENPA complex localizes to the centromere
output	[Complex:606282] CCAN:DNA:CASC5:Mis18 complex:HJURP complex:CENPA:H4 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:606349] Mis18 complex binds the centromere [Homo sapiens]
releaseDate	2010-06-15
reviewed	[InstanceEdit:847690] Almouzni-Pettinotti, G, Dunleavy, EM, 2010-05-30 [InstanceEdit:877422] Foltz, DR, 2010-06-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:1104283] R-HSA-606326.2
summation	[Summation:606281] The HJURP complex binds free, newly synthesized CENPA-H4 tet...
(hasEvent)	[Pathway:606279] Deposition of new CENPA-containing nucleosomes at the centromere [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:606289] New CENPA-containing nucleosomes are deposited at the centromere [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9785685] Update Tracker - [Reaction:606326] HJURP:CENPA complex localizes to the centromere - v51:[addLiteratureReference] [_UpdateTracker:9790244] Update Tracker - [Reaction:606326] HJURP:CENPA complex localizes to the centromere - v34:[modifyText, removeLiteratureReference]
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