Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person UniProt:P51970 NDUFA8

Class:IdReferenceGeneProduct:60628
_chainChangeLoginitiator methionine:1 added on Fri February 6 2015;chain:2-172 added on Fri February 6 2015;initiator methionine:1 for 60628 removed on Fri Nov 03 2023;initiator methionine: for 60628 added on Fri Nov 03 2023;initiator methionine: for 60628 removed on Fri Aug 15 2025;initiator methionine:1 for 60628 added on Fri Aug 15 2025
_displayNameUniProt:P51970 NDUFA8
_timestamp2025-08-15 21:39:41
chaininitiator methionine:1
chain:2-172
checksumE1647472B69E1149
commentFUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis (PubMed:27626371, PubMed:32385911, PubMed:33153867). Complex I functions in the transfer of electrons from NADH to the respiratory chain (PubMed:27626371). The immediate electron acceptor for the enzyme is believed to be ubiquinone (PubMed:27626371).SUBUNIT Complex I is composed of 45 different subunits.INTERACTION Contains four C-X9-C motifs that are predicted to form a helix-coil-helix structure, permitting the formation of intramolecular disulfide bonds.PTM May contain intrachain disulfide bonds, as evidenced by its electrophoretic mobility under reducing vs non-reducing conditions.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I NDUFA8 subunit family.
descriptionrecommendedName: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 alternativeName: Complex I-19kD shortName: CI-19kD alternativeName: Complex I-PGIV shortName: CI-PGIV alternativeName: NADH-ubiquinone oxidoreductase 19 kDa subunit
geneNameNDUFA8
identifierP51970
isSequenceChangedFALSE
keyword3D-structure
Direct protein sequencing
Disease variant
Disulfide bond
Electron transport
Membrane
Mitochondrion
Mitochondrion inner membrane
Primary mitochondrial disease
Proteomics identification
Reference proteome
Repeat
Respiratory chain
Transport
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
[InstanceEdit:9963647] Weiser, Joel, 2025-08-15
nameNDUFA8
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8987963] ENSEMBL:ENSG00000119421 NDUFA8 [Homo sapiens]
secondaryIdentifierNDUA8_HUMAN
B1AM93
Q9Y6N0
sequenceLength172
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:60627] NDUFA8 [mitochondrial inner membrane] [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by UniProt:P51970 NDUFA8 (60628)
Follow Reactome