Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:P03901 MT-ND4L
| Class:Id | ReferenceGeneProduct:60614 |
|---|---|
| _chainChangeLog | chain:1-98 added on Fri February 6 2015 |
| _displayName | UniProt:P03901 MT-ND4L |
| _timestamp | 2025-02-21 19:51:09 |
| chain | chain:1-98 |
| checksum | 24B91F1DCDB0BE22 |
| comment | FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:28844695). Part of the enzyme membrane arm which is embedded in the lipid bilayer and involved in proton translocation (PubMed:28844695).CATALYTIC ACTIVITY a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)SUBUNIT Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I subunit 4L family. |
| description | recommendedName: NADH-ubiquinone oxidoreductase chain 4L ecNumber evidence="9"7.1.1.2 alternativeName: fullName evidence="7"NADH dehydrogenase subunit 4L shortName evidence="7"ND4L |
| geneName | MT-ND4L MTND4L NADH4L ND4L |
| identifier | P03901 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant Electron transport Leber hereditary optic neuropathy Membrane Mitochondrion Mitochondrion inner membrane NAD Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Translocase Transmembrane Transmembrane helix Transport Ubiquinone |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MT-ND4L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8988538] ENSEMBL:ENSG00000212907 MT-ND4L [Homo sapiens] |
| secondaryIdentifier | NU4LM_HUMAN |
| sequenceLength | 98 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:60613] MT-ND4L [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P03901 MT-ND4L (60614)
