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Details on Person UniProt:O75489 NDUFS3
Class:Id
ReferenceGeneProduct:60604
_chainChangeLog
transit peptide:1-36 added on Sat February 7 2015;chain:37-264 added on Sat February 7 2015
_displayName
UniProt:O75489 NDUFS3
_timestamp
2025-02-21 20:11:58
chain
transit peptide:1-36 chain:37-264
checksum
C058D62779BEF17B
comment
FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:14729820, PubMed:30140060). Essential for the catalytic activity and assembly of complex I (PubMed:14729820, PubMed:24028823, PubMed:30140060).CATALYTIC ACTIVITY a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)SUBUNIT Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits (PubMed:12611891). Interacts with NDUFAF3 (PubMed:19463981). Interacts with RAB5IF (PubMed:31536960). Found in subcomplexes containing subunits NDUFS2, MT-ND1 and NDUFA13 (PubMed:17209039, PubMed:18826940).INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I 30 kDa subunit family.
3D-structure Alternative splicing Direct protein sequencing Disease variant Electron transport Membrane Mitochondrion Mitochondrion inner membrane NAD Oxidoreductase Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Transit peptide Translocase Transport Ubiquinone
