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Details on Person UniProt:P53370 NUDT6
| Class:Id | ReferenceGeneProduct:60592 |
|---|---|
| _chainChangeLog | chain:1-316 added on Fri February 6 2015 |
| _displayName | UniProt:P53370 NUDT6 |
| _timestamp | 2026-02-20 22:57:55 |
| chain | chain:1-316 |
| checksum | 41EC95893B52180A |
| comment | FUNCTION Mediates the hydrolysis of some nucleoside diphosphate derivatives, such as NADH and FAD (in vitro) (PubMed:37343711). May contribute to the regulation of cell proliferation (PubMed:11266510).CATALYTIC ACTIVITY NADH + H2O = reduced beta-nicotinamide D-ribonucleotide + AMP + 2 H(+)CATALYTIC ACTIVITY FAD + H2O = FMN + AMP + 2 H(+)COFACTOR Mn(2+) has a strong inhibitory effet on ADP-ribose diphosphatase activity.SUBUNIT Monomer and homodimer.SUBCELLULAR LOCATION Localizes exclusively to the mitochondria.SUBCELLULAR LOCATION Additional isoforms seem to exist.TISSUE SPECIFICITY Detected in liver, kidney and esophagus (at protein level). Ubiquitous.MISCELLANEOUS This protein is coded from a FGF2 (BFGF) gene antisense transcript.SIMILARITY Belongs to the Nudix hydrolase family.CAUTION The rat protein was reported to play a role in DNA repair, based on its ability to complement E.coli deficient in the DNA repair enzyme mutT that hydrolyzes oxidized guanine nucleotides (By similarity). PubMed:17569023 found no such activity, neither for the human nor the rat protein. |
| description | recommendedName: fullName evidence="10"Nudix hydrolase 6 alternativeName: fullName evidence="7"Antisense basic fibroblast growth factor alternativeName: FAD diphosphatase NUDT6 ecNumber evidence="5"3.6.1.18 alternativeName: NADH pyrophosphatase NUDT6 ecNumber evidence="5"3.6.1.22 alternativeName: Nucleoside diphosphate-linked moiety X motif 6 shortName: Nudix motif 6 alternativeName: Protein GFG |
| geneName | NUDT6 FGF2AS |
| identifier | P53370 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cytoplasm Hydrolase Mitochondrion Nucleus Proteomics identification Reference proteome |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NUDT6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8987979] ENSEMBL:ENSG00000170917 NUDT6 [Homo sapiens] |
| secondaryIdentifier | NUDT6_HUMAN A8K756 O95097 Q9UQD9 |
| sequenceLength | 316 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151401] UniProt:P53370-2 NUDT6 [Homo sapiens] [ReferenceIsoform:404349] UniProt:P53370-1 NUDT6 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:6809213] NUDT6 [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P53370 NUDT6 (60592)
