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Details on Person UniProt:P03905 MT-ND4
| Class:Id | ReferenceGeneProduct:60562 |
|---|---|
| _chainChangeLog | chain:1-459 added on Fri February 6 2015 |
| _displayName | UniProt:P03905 MT-ND4 |
| _timestamp | 2025-02-21 20:12:20 |
| chain | chain:1-459 |
| checksum | 2EEE581F3BD270AF |
| comment | FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:15250827, PubMed:8344246, PubMed:8644732). Essential for the catalytic activity and assembly of complex I (PubMed:15250827, PubMed:8344246, PubMed:8644732).CATALYTIC ACTIVITY a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)SUBUNIT Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I subunit 4 family. |
| description | recommendedName: NADH-ubiquinone oxidoreductase chain 4 ecNumber evidence="6 12 13"7.1.1.2 alternativeName: NADH dehydrogenase subunit 4 |
| geneName | MT-ND4 MTND4 NADH4 ND4 |
| identifier | P03905 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disease variant Dystonia Electron transport Leber hereditary optic neuropathy MELAS syndrome Membrane Mitochondrion Mitochondrion inner membrane NAD Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Translocase Transmembrane Transmembrane helix Transport Ubiquinone |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MT-ND4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998480] ENSEMBL:ENSG00000198886 MT-ND4 [Homo sapiens] |
| secondaryIdentifier | NU4M_HUMAN Q6RL39 Q6RQN9 Q8HNR8 |
| sequenceLength | 459 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:60561] MT-ND4 [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P03905 MT-ND4 (60562)
