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Details on Person UniProt:P03891 MT-ND2
| Class:Id | ReferenceGeneProduct:60554 |
|---|---|
| _chainChangeLog | chain:1-347 added on Sat February 7 2015 |
| _displayName | UniProt:P03891 MT-ND2 |
| _timestamp | 2025-02-21 20:01:57 |
| chain | chain:1-347 |
| checksum | C06FD982317C3F2D |
| comment | FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:16996290). Essential for the catalytic activity and assembly of complex I (PubMed:16996290).CATALYTIC ACTIVITY a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)SUBUNIT Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits. Interacts with TMEM242 (PubMed:33753518).SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.DISEASE Disease susceptibility may be associated with variants affecting the gene represented in this entry.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I subunit 2 family. |
| description | recommendedName: fullName evidence="13"NADH-ubiquinone oxidoreductase chain 2 ecNumber evidence="5"7.1.1.2 alternativeName: NADH dehydrogenase subunit 2 |
| geneName | MT-ND2 MTND2 NADH2 ND2 |
| identifier | P03891 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alzheimer disease Amyloidosis Disease variant Electron transport Leber hereditary optic neuropathy Leigh syndrome Membrane Mitochondrion Mitochondrion inner membrane NAD Neurodegeneration Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Translocase Transmembrane Transmembrane helix Transport Ubiquinone |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MT-ND2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991434] ENSEMBL:ENSG00000198763 MT-ND2 [Homo sapiens] |
| secondaryIdentifier | NU2M_HUMAN Q34769 Q9TGI0 Q9TGI1 Q9TGI2 Q9TGI3 Q9TGI4 |
| sequenceLength | 347 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:60553] MT-ND2 [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P03891 MT-ND2 (60554)
