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Details on Person UniProt:P03886 MT-ND1
| Class:Id | ReferenceGeneProduct:60552 |
|---|---|
| _chainChangeLog | chain:1-318 added on Fri February 6 2015 |
| _displayName | UniProt:P03886 MT-ND1 |
| _timestamp | 2025-02-21 18:59:33 |
| chain | chain:1-318 |
| checksum | 2F771ACB95002591 |
| comment | FUNCTION Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor (PubMed:1959619). Essential for the catalytic activity and assembly of complex I (PubMed:1959619, PubMed:26929434).CATALYTIC ACTIVITY a ubiquinone + NADH + 5 H(+)(in) = a ubiquinol + NAD(+) + 4 H(+)(out)SUBUNIT Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.INTERACTION The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE Disease susceptibility may be associated with variants affecting the gene represented in this entry.DISEASE The gene represented in this entry may be involved in disease pathogenesis.SIMILARITY Belongs to the complex I subunit 1 family. |
| description | recommendedName: NADH-ubiquinone oxidoreductase chain 1 ecNumber evidence="10"7.1.1.2 alternativeName: NADH dehydrogenase subunit 1 |
| geneName | MT-ND1 MTND1 NADH1 ND1 |
| identifier | P03886 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alzheimer disease Amyloidosis Diabetes mellitus Disease variant Electron transport Epilepsy Leber hereditary optic neuropathy MELAS syndrome Membrane Mitochondrion Mitochondrion inner membrane NAD Neurodegeneration Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Translocase Transmembrane Transmembrane helix Transport Ubiquinone |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MT-ND1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001932] ENSEMBL:ENSG00000198888 MT-ND1 [Homo sapiens] |
| secondaryIdentifier | NU1M_HUMAN C0JKH6 Q37523 |
| sequenceLength | 318 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:60551] MT-ND1 [mitochondrial inner membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P03886 MT-ND1 (60552)
