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Query author contributions in Reactome

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Details on Person NTHL1 [nucleoplasm]

Class:IdEntityWithAccessionedSequence:60537
_displayNameNTHL1 [nucleoplasm]
_timestamp2025-09-30 21:09:14
compartment[Compartment:7660] nucleoplasm
endCoordinate304
modified[InstanceEdit:110148] Matthews, L, 2004-01-28 20:00:00
[InstanceEdit:110175] Matthews, L, 2004-01-29 08:00:00
[InstanceEdit:113604] Schmidt, EE, 2004-06-09 05:34:08
[InstanceEdit:141739] Matthews, L, 2004-10-03 14:16:35
[InstanceEdit:3132750] Wu, G, 2013-02-13
[InstanceEdit:3632907] Wu, G, 2013-05-28
[InstanceEdit:9629976] Orlic-Milacic, Marija, 2018-11-26
[InstanceEdit:9967561] D'Eustachio, Peter, 2025-09-30
nameNTHL1
hNTH1
Endonuclease III-like protein 1 (EC 4.2.99.18)
Endonuclease III-like protein 1
referenceEntity[ReferenceGeneProduct:60538] UniProt:P78549 NTHL1 [Homo sapiens]
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:368224] R-HSA-60537.3
startCoordinate23
(activeUnit)[CatalystActivity:5643989] oxidized purine nucleobase lesion DNA N-glycosylase activity of NTHL1:FapyA-dsDNA [nucleoplasm]
[CatalystActivity:5643994] oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1:Tg-dsDNA [nucleoplasm]
[CatalystActivity:5643996] oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1:DHU-dsDNA [nucleoplasm]
[CatalystActivity:5643999] oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1:Cg-dsDNA [nucleoplasm]
(hasComponent)[Complex:110177] NTHL1:Tg-dsDNA [nucleoplasm] [Homo sapiens]
[Complex:110179] NTHL1:Cg-dsDNA [nucleoplasm] [Homo sapiens]
[Complex:110181] NTHL1:DHU-dsDNA [nucleoplasm] [Homo sapiens]
[Complex:110183] NTHL1:FapyA-dsDNA [nucleoplasm] [Homo sapiens]
[Complex:110193] NTHL1:AP-dsDNA [nucleoplasm] [Homo sapiens]
(input)[Reaction:110208] NTHL1 glycosylase mediated recognition and binding of cytosine glycol [Homo sapiens]
[Reaction:110211] NTHL1 glycosylase mediated recognition and binding of thymine glycol [Homo sapiens]
[Reaction:110212] NTHL1 glycosylase mediated recognition and binding of dihydrouracil [Homo sapiens]
[Reaction:110213] NTHL1 glycosylase mediated recognition and binding of formamidopyrimidine (FapyA) [Homo sapiens]
(normalEntity)[EntityFunctionalStatus:9630216] loss_of_function of NTHL1 truncation mutants [nucleoplasm]
(output)[Reaction:110352] Displacement of NTHL1 glycosylase by APEX1 at the AP site [Homo sapiens]
(physicalEntity)[CatalystActivity:110222] oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity of NTHL1 [nucleoplasm]
(updatedInstance)[_UpdateTracker:9876958] Update Tracker - [EntityWithAccessionedSequence:60537] NTHL1 [nucleoplasm] - v44:[modifyEndCoordinate]
[_UpdateTracker:9886902] Update Tracker - [EntityWithAccessionedSequence:60537] NTHL1 [nucleoplasm] - v45:[addName]
[_UpdateTracker:9900327] Update Tracker - [EntityWithAccessionedSequence:60537] NTHL1 [nucleoplasm] - v68:[modifyStartCoordinate]
[_UpdateTracker:9972478] Update Tracker - [EntityWithAccessionedSequence:60537] NTHL1 [nucleoplasm] - v95:[modifyEndCoordinate, modifyStartCoordinate]
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No pathways have been reviewed or authored by NTHL1 [nucleoplasm] (60537)
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