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Details on Person UniProt:P49279 SLC11A1

Class:Id	ReferenceGeneProduct:60474
_chainChangeLog	chain:1-550 added on Sat February 7 2015
_displayName	UniProt:P49279 SLC11A1
_timestamp	2025-05-21 21:44:31
chain	chain:1-550
checksum	AA670763D52EEECC
comment	FUNCTION Macrophage-specific antiporter that fluxes metal ions in either direction against a proton gradient. Localized to late endosomal lysosomal membranes, delivers bivalent cations from the cytosol into these acidic compartments where they may directly affect antimicrobial activity (PubMed:11237855). Involved in iron metabolism and host natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis of its protective enzymes (Probable).CATALYTIC ACTIVITY Zn(2+)(in) + H(+)(out) = Zn(2+)(out) + H(+)(in)CATALYTIC ACTIVITY Fe(2+)(in) + H(+)(out) = Fe(2+)(out) + H(+)(in)CATALYTIC ACTIVITY Mn(2+)(in) + H(+)(out) = Mn(2+)(out) + H(+)(in)SUBCELLULAR LOCATION Macrophages; peripheral blood leukocytes, lung, spleen and liver.INDUCTION In response to lymphokine or bacterial products.POLYMORPHISM Genetic variation in SLC11A1 is associated with susceptibility to infection with Mycobacterium ulcerans [MIM:610446].POLYMORPHISM Genetic variations in SLC11A1 determine Mycobacterium tuberculosis susceptibility [MIM:607948].SIMILARITY Belongs to the NRAMP family.
description	recommendedName: fullName evidence="11"Natural resistance-associated macrophage protein 1 shortName evidence="9"NRAMP 1 alternativeName: Solute carrier family 11 member 1
geneName	SLC11A1 LSH NRAMP NRAMP1
identifier	P49279
isSequenceChanged	FALSE
keyword	3D-structure Alternative splicing Endosome Glycoprotein Ion transport Iron Iron transport Lysosome Membrane Proteomics identification Reference proteome Transmembrane Transmembrane helix Transport
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9948485] Weiser, Joel, 2025-05-21
name	SLC11A1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8999038] ENSEMBL:ENSG00000018280 SLC11A1 [Homo sapiens]
secondaryIdentifier	NRAM1_HUMAN C0H5Y3
sequenceLength	550
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8971572] UniProt:P49279-1 SLC11A1 [Homo sapiens] [ReferenceIsoform:8971573] UniProt:P49279-2 SLC11A1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:437103] SLC11A1 [late endosome membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803283] SLC11A1 [tertiary granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803331] SLC11A1 [ficolin-1-rich granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6803350] SLC11A1 [plasma membrane] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:P49279 SLC11A1 (60474)