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Details on Person UniProt:P55055 NR1H2
| Class:Id | ReferenceGeneProduct:60462 |
|---|---|
| _chainChangeLog | chain:1-460 added on Sat February 7 2015 |
| _displayName | UniProt:P55055 NR1H2 |
| _timestamp | 2024-11-03 20:20:26 |
| chain | chain:1-460 |
| checksum | 9465A6FFB7FCFD2F |
| comment | FUNCTION Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity (PubMed:25661920). Binds preferentially to double-stranded oligonucleotide direct repeats having the consensus half-site sequence 5'-AGGTCA-3' and 4-nt spacing (DR-4). Regulates cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8; DLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles (By similarity). Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity). Plays an anti-inflammatory role during the hepatic acute phase response by acting as a corepressor: inhibits the hepatic acute phase response by preventing dissociation of the N-Cor corepressor complex (PubMed:20159957).SUBUNIT Forms a heterodimer with RXR. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner (PubMed:25661920). Interacts (when sumoylated) with GPS2; interaction with GPS2 onto hepatic acute phase protein promoters prevents N-Cor corepressor complex dissociation (PubMed:20159957). Interacts with ABCA12 and ABCA1; this interaction is required for ABCA1 localization to the cell surface and is necessary for its normal activity and stability (PubMed:23931754).INTERACTION Ubiquitous.PTM Sumoylated by SUMO2 at Lys-409 and Lys-447 during the hepatic acute phase response, leading to promote interaction with GPS2 and prevent N-Cor corepressor complex dissociation.SIMILARITY Belongs to the nuclear hormone receptor family. NR1 subfamily. |
| description | recommendedName: Oxysterols receptor LXR-beta alternativeName: Liver X receptor beta alternativeName: Nuclear receptor NER alternativeName: Nuclear receptor subfamily 1 group H member 2 alternativeName: Ubiquitously-expressed nuclear receptor |
| geneName | NR1H2 LXRB NER UNR |
| identifier | P55055 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing DNA-binding Isopeptide bond Metal-binding Nucleus Proteomics identification Receptor Reference proteome Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NR1H2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9003104] ENSEMBL:ENSG00000131408 NR1H2 [Homo sapiens] |
| secondaryIdentifier | NR1H2_HUMAN A8K490 B4DNM6 E7EWA6 Q12970 Q5I0Y1 |
| sequenceLength | 460 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8967096] UniProt:P55055-1 NR1H2 [Homo sapiens] [ReferenceIsoform:8967097] UniProt:P55055-2 NR1H2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:375500] NR1H2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:4720435] polySUMO2,3-K409,K447-NR1H2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9024357] NR1H2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9619753] NR1H2 [cytosol] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:4720440] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 409 [GroupModifiedResidue:4720445] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 447 |
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No pathways have been reviewed or authored by UniProt:P55055 NR1H2 (60462)
