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Details on Person UniProt:Q9Y466 NR2E1
| Class:Id | ReferenceGeneProduct:60430 |
|---|---|
| _chainChangeLog | chain:1-385 added on Fri February 6 2015 |
| _displayName | UniProt:Q9Y466 NR2E1 |
| _timestamp | 2026-02-20 21:32:36 |
| chain | chain:1-385 |
| checksum | 39181A42A2FB79C2 |
| comment | FUNCTION Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). May be required to pattern anterior brain differentiation. Involved in the regulation of retinal development and essential for vision. During retinogenesis, regulates PTEN-Cyclin D expression via binding to the promoter region of PTEN and suppressing its activity (By similarity). May be involved in retinoic acid receptor (RAR) regulation in retinal cells.SUBUNIT Monomer. Interacts with ATN1; the interaction represses the transcription.SUBCELLULAR LOCATION Brain specific. Present in all brain sections tested, highest levels in the caudate nucleus and hippocampus, weakest levels in the thalamus.SIMILARITY Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| description | recommendedName: Nuclear receptor subfamily 2 group E member 1 alternativeName: Nuclear receptor TLX alternativeName: Protein tailless homolog shortName: Tll shortName: hTll |
| geneName | NR2E1 TLX |
| identifier | Q9Y466 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Activator Alternative splicing Developmental protein DNA-binding Metal-binding Nucleus Proteomics identification Receptor Reference proteome Repressor Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | NR2E1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002505] ENSEMBL:ENSG00000112333 NR2E1 [Homo sapiens] |
| secondaryIdentifier | NR2E1_HUMAN Q6ZMP8 |
| sequenceLength | 385 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966665] UniProt:Q9Y466-1 NR2E1 [Homo sapiens] [ReferenceIsoform:8966666] UniProt:Q9Y466-2 NR2E1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:376207] NR2E1 [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9Y466 NR2E1 (60430)
