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Details on Person UniProt:Q14916 SLC17A1
| Class:Id | ReferenceGeneProduct:60412 |
|---|---|
| _chainChangeLog | chain:1-467 added on Fri February 6 2015 |
| _displayName | UniProt:Q14916 SLC17A1 |
| _timestamp | 2026-02-20 22:57:45 |
| chain | chain:1-467 |
| checksum | 10FE6C7E202BCFF7 |
| comment | FUNCTION Important for the resorption of phosphate by the kidney (PubMed:7826357). May be involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:7826357). Plays a role in urate transport in the kidney (PubMed:25252215, PubMed:27906618).CATALYTIC ACTIVITY 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in)CATALYTIC ACTIVITY urate(out) = urate(in)BIOPHYSICOCHEMICAL PROPERTIES Interacts with PDZK1.INTERACTION Expressed in kidney cortex, liver and brain but not in other tissues.SIMILARITY Belongs to the major facilitator superfamily. Sodium/anion cotransporter family.CAUTION It is uncertain whether Met-1 or Met-3 is the initiator.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Sodium-dependent phosphate transport protein 1 alternativeName: Na(+)/PI cotransporter 1 alternativeName: Na/Pi-4 alternativeName: Renal Na(+)-dependent phosphate cotransporter 1 alternativeName: Renal sodium-dependent phosphate transport protein 1 shortName: Renal sodium-phosphate transport protein 1 alternativeName: Sodium/phosphate cotransporter 1 alternativeName: Solute carrier family 17 member 1 |
| geneName | SLC17A1 NPT1 |
| identifier | Q14916 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Glycoprotein Ion transport Membrane Reference proteome Sodium Sodium transport Symport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | SLC17A1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994383] ENSEMBL:ENSG00000124568 SLC17A1 [Homo sapiens] |
| secondaryIdentifier | NPT1_HUMAN A8K418 O60761 Q13783 Q3MIP5 Q5MJP8 Q5TB83 Q96KL8 |
| sequenceLength | 467 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:385716] UniProt:Q14916-2 SLC17A1 [Homo sapiens] [ReferenceIsoform:405760] UniProt:Q14916-1 SLC17A1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:433658] SLC17A1 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14916 SLC17A1 (60412)
