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Details on Person UniProt:O75323 NIPSNAP2
| Class:Id | ReferenceGeneProduct:60408 |
|---|---|
| _chainChangeLog | chain:1-286 added on Fri February 6 2015;chain:1-286 for 60408 removed on Fri Aug 09 2024;transit peptide:1-23 for 60408 added on Fri Aug 09 2024;chain:24-286 for 60408 added on Fri Aug 09 2024 |
| _displayName | UniProt:O75323 NIPSNAP2 |
| _timestamp | 2025-08-15 22:16:16 |
| chain | transit peptide:1-23 chain:24-286 |
| checksum | 7ED85297E4DC9D08 |
| comment | FUNCTION Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (PubMed:30982665).SUBUNIT Interacts with CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY (PubMed:30982665). Interacts with ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (PubMed:30982665). Interacts with VDAC1 (PubMed:26387735).INTERACTION Widely expressed (PubMed:9615231). Most abundant in heart and skeletal muscle (PubMed:9615231).SIMILARITY Belongs to the NipSnap family. |
| description | recommendedName: Protein NipSnap homolog 2 shortName: NipSnap2 alternativeName: fullName evidence="7"Glioblastoma-amplified sequence |
| geneName | NIPSNAP2 GBAS |
| identifier | O75323 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Autophagy Mitochondrion Proteomics identification Reference proteome Transit peptide |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | NIPSNAP2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8991426] ENSEMBL:ENSG00000146729 NIPSNAP2 [Homo sapiens] |
| secondaryIdentifier | NIPS2_HUMAN C9IYJ3 O43801 Q53X96 |
| sequenceLength | 286 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976639] UniProt:O75323-1 NIPSNAP2 [Homo sapiens] [ReferenceIsoform:8976640] UniProt:O75323-2 NIPSNAP2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9714668] NIPSNAP2 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O75323 NIPSNAP2 (60408)
