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Details on Person UniProt:P30419 NMT1
| Class:Id | ReferenceGeneProduct:60307 |
|---|---|
| _chainChangeLog | chain:1-496 added on Fri February 6 2015 |
| _displayName | UniProt:P30419 NMT1 |
| _timestamp | 2025-02-21 19:30:20 |
| chain | chain:1-496 |
| checksum | 7661140D3837BE7A |
| comment | FUNCTION Adds a myristoyl group to the N-terminal glycine residue of certain cellular and viral proteins (PubMed:22865860, PubMed:25255805, PubMed:32686708, PubMed:34999170, PubMed:9353336, PubMed:9506952). Also able to mediate N-terminal lysine myristoylation of proteins: catalyzes myristoylation of ARF6 on both 'Gly-2' and 'Lys-3' (PubMed:32103017, PubMed:32111831). Lysine myristoylation is required to maintain ARF6 on membranes during the GTPase cycle (PubMed:32103017).CATALYTIC ACTIVITY N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)CATALYTIC ACTIVITY N-terminal glycyl-L-lysyl-[protein] + tetradecanoyl-CoA = N-terminal glycyl-(N(6)-tetradecanoyl)-L-lysyl-[protein] + CoA + H(+)BIOPHYSICOCHEMICAL PROPERTIES kcat is 0.41 sec(-1) with tetradecanoyl-CoA as substrate.INTERACTION Copurifies with ribosomes.ALTERNATIVE PRODUCTS Heart, gut, kidney, liver and placenta.SIMILARITY Belongs to the NMT family. |
| description | recommendedName: fullName evidence="17"Glycylpeptide N-tetradecanoyltransferase 1 ecNumber evidence="4 5 10 11"2.3.1.97 alternativeName: Myristoyl-CoA:protein N-myristoyltransferase 1 shortName evidence="14"HsNMT1 shortName: NMT 1 shortName: Type I N-myristoyltransferase alternativeName: Peptide N-myristoyltransferase 1 alternativeName: fullName evidence="17"Protein-lysine myristoyltransferase NMT1 ecNumber evidence="6 7"2.3.1.- |
| geneName | NMT1 NMT |
| identifier | P30419 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acyltransferase Alternative splicing Cytoplasm Membrane Phosphoprotein Proteomics identification Reference proteome Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | NMT1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990278] ENSEMBL:ENSG00000136448 NMT1 [Homo sapiens] |
| secondaryIdentifier | NMT1_HUMAN A8K7C1 Q9UE09 |
| sequenceLength | 496 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:151159] UniProt:P30419-2 NMT1 [Homo sapiens] [ReferenceIsoform:403601] UniProt:P30419-1 NMT1 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:60306] NMT1 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P30419 NMT1 (60307)
