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Details on Person UniProt:Q14957 GRIN2C
| Class:Id | ReferenceGeneProduct:60299 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Sat February 7 2015;chain:20-1233 added on Sat February 7 2015 |
| _displayName | UniProt:Q14957 GRIN2C |
| _timestamp | 2026-02-20 21:42:10 |
| chain | signal peptide:1-19 chain:20-1233 |
| checksum | 7B1F2F7995C0D689 |
| comment | FUNCTION Component of N-methyl-D-aspartate (NMDA) receptors (NMDARs) that function as heterotetrameric, ligand-gated cation channels with high calcium permeability and voltage-dependent block by Mg(2+) (PubMed:26875626, PubMed:36309015). Participates in synaptic plasticity for learning and memory formation by contributing to the slow phase of excitatory postsynaptic current and long-term synaptic potentiation (By similarity). Channel activation requires binding of the neurotransmitter L-glutamate to the GluN2 subunit, glycine or D-serine binding to the GluN1 subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626, PubMed:36309015). NMDARs mediate simultaneously the potassium efflux and the influx of calcium and sodium (By similarity). Each GluN2 subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, Ca2(+) permeability, and binding to allosteric modulators (PubMed:26875626).CATALYTIC ACTIVITY Ca(2+)(in) = Ca(2+)(out)CATALYTIC ACTIVITY Na(+)(in) = Na(+)(out)CATALYTIC ACTIVITY K(+)(in) = K(+)(out)SUBUNIT Heterotetramer (PubMed:36309015). Forms heterotetrameric channels composed of two GluN1/zeta subunits (GRIN1), and two identical GluN2/epsilon subunits (GRIN2A, GRIN2B, GRIN2C or GRIN2D) or GluN3 subunits (GRIN3A or GRIN3B) (in vitro) (PubMed:26875626, PubMed:36309015). In vivo, the subunit composition may depend on the expression levels of the different subunits (Probable). Interacts with PDZ domains of PATJ and DLG4 (By similarity). Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes (PubMed:21300787).INTERACTION Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas.DOMAIN A hydrophobic region that gives rise to the prediction of a transmembrane span does not cross the membrane, but is part of a discontinuously helical region that dips into the membrane and is probably part of the pore and of the selectivity filter.SIMILARITY Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily. |
| description | recommendedName: fullName evidence="15"Glutamate receptor ionotropic, NMDA 2C shortName evidence="5"GluN2C alternativeName: fullName evidence="6"Glutamate [NMDA] receptor subunit epsilon-3 alternativeName: N-methyl D-aspartate receptor subtype 2C shortName evidence="5"NMDAR2C shortName evidence="14"NR2C |
| geneName | GRIN2C NMDAR2C |
| identifier | Q14957 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cell membrane Disulfide bond Glycoprotein Ion channel Ion transport Ligand-gated ion channel Magnesium Membrane Phosphoprotein Postsynaptic cell membrane Proteomics identification Receptor Reference proteome Signal Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9841277] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | GRIN2C |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999640] ENSEMBL:ENSG00000161509 GRIN2C [Homo sapiens] |
| secondaryIdentifier | NMDE3_HUMAN B2RTT1 |
| sequenceLength | 1233 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:419560] GRIN2C [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9609761] GRIN2C [endoplasmic reticulum membrane] [Homo sapiens] [EntityWithAccessionedSequence:9612189] p-Y-GRIN2C [plasma membrane] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:9612188] O4'-phospho-L-tyrosine at unknown position |
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No pathways have been reviewed or authored by UniProt:Q14957 GRIN2C (60299)
