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Details on Person UniProt:P78367 NKX3-2
| Class:Id | ReferenceGeneProduct:60249 |
|---|---|
| _chainChangeLog | chain:1-333 added on Sat February 7 2015 |
| _displayName | UniProt:P78367 NKX3-2 |
| _timestamp | 2024-11-03 20:20:22 |
| chain | chain:1-333 |
| checksum | 8C406E188D27780B |
| comment | FUNCTION Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity).INTERACTION Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the NK-3 homeobox family. |
| description | recommendedName: Homeobox protein Nkx-3.2 alternativeName: Bagpipe homeobox protein homolog 1 alternativeName: Homeobox protein NK-3 homolog B |
| geneName | NKX3-2 BAPX1 NKX3B |
| identifier | P78367 |
| isSequenceChanged | FALSE |
| keyword | DNA-binding Dwarfism Homeobox Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NKX3-2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8985367] ENSEMBL:ENSG00000109705 NKX3-2 [Homo sapiens] |
| secondaryIdentifier | NKX32_HUMAN Q2M2I7 |
| sequenceLength | 333 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8985289] NKX3-2 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P78367 NKX3-2 (60249)
