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Details on Person UniProt:O96000 NDUFB10
| Class:Id | ReferenceGeneProduct:60195 |
|---|---|
| _chainChangeLog | chain:1-172 added on Fri February 6 2015 |
| _displayName | UniProt:O96000 NDUFB10 |
| _timestamp | 2024-11-03 20:06:29 |
| chain | chain:1-172 |
| checksum | A5E6561402F4486A |
| comment | FUNCTION Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.SUBUNIT Complex I is composed of 45 different subunits (PubMed:12611891, PubMed:27626371, PubMed:28040730). Interacts with CHCHD4; assists NDUFB10 oxidation, folding and import into mitochondrion (PubMed:28040730).INTERACTION The formation of intramolecular disulfide bonds is assisted by CHCHD4 and ensures folding, import into the mitochondrion and is required for the function in mitochondrial respiratory chain complex I assembly.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I NDUFB10 subunit family. |
| description | recommendedName: NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 alternativeName: Complex I-PDSW shortName: CI-PDSW alternativeName: NADH-ubiquinone oxidoreductase PDSW subunit |
| geneName | NDUFB10 |
| identifier | O96000 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disease variant Electron transport Membrane Mitochondrion Mitochondrion inner membrane Phosphoprotein Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NDUFB10 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8997298] ENSEMBL:ENSG00000140990 NDUFB10 [Homo sapiens] |
| secondaryIdentifier | NDUBA_HUMAN Q96II6 |
| sequenceLength | 172 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8976633] UniProt:O96000-1 NDUFB10 [Homo sapiens] [ReferenceIsoform:8976634] UniProt:O96000-2 NDUFB10 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:60194] NDUFB10 [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O96000 NDUFB10 (60195)
