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Details on Person UniProt:O43678 NDUFA2
| Class:Id | ReferenceGeneProduct:60179 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-99 added on Sat February 7 2015;initiator methionine:1 for 60179 removed on Fri Nov 03 2023;initiator methionine: for 60179 added on Fri Nov 03 2023;initiator methionine: for 60179 removed on Fri Aug 15 2025;initiator methionine:1 for 60179 added on Fri Aug 15 2025 |
| _displayName | UniProt:O43678 NDUFA2 |
| _timestamp | 2025-08-15 21:32:05 |
| chain | initiator methionine:1 chain:2-99 |
| checksum | EF026F193CAF1DF7 |
| comment | FUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SUBUNIT Complex I is composed of 45 different subunits.SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I NDUFA2 subunit family. |
| description | recommendedName: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 alternativeName: Complex I-B8 shortName: CI-B8 alternativeName: NADH-ubiquinone oxidoreductase B8 subunit |
| geneName | NDUFA2 |
| identifier | O43678 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing Disulfide bond Electron transport Membrane Mitochondrion Mitochondrion inner membrane Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | NDUFA2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002489] ENSEMBL:ENSG00000131495 NDUFA2 [Homo sapiens] |
| secondaryIdentifier | NDUA2_HUMAN D6RJD6 Q6IAY8 |
| sequenceLength | 99 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8969302] UniProt:O43678-1 NDUFA2 [Homo sapiens] [ReferenceIsoform:8969303] UniProt:O43678-2 NDUFA2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:60178] NDUFA2 [mitochondrial inner membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O43678 NDUFA2 (60179)
