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Details on Person UniProt:P07196 NEFL
| Class:Id | ReferenceGeneProduct:60147 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Sat February 7 2015;chain:2-543 added on Sat February 7 2015;initiator methionine:1 for 60147 removed on Fri Nov 03 2023;initiator methionine: for 60147 added on Fri Nov 03 2023;initiator methionine: for 60147 removed on Fri Aug 15 2025;initiator methionine:1 for 60147 added on Fri Aug 15 2025 |
| _displayName | UniProt:P07196 NEFL |
| _timestamp | 2025-08-15 21:32:09 |
| chain | initiator methionine:1 chain:2-543 |
| checksum | 98C1712D8ACFF33A |
| comment | FUNCTION Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity).SUBUNIT Forms homodimers (in vitro) (By similarity). Forms heterodimers with NEFH or NEFM; which can further hetero-oligomerize (in vitro) (By similarity). Forms heterodimers with INA (in vitro) (By similarity). Interacts with ARHGEF28. Interacts with TRIM2.INTERACTION The extra mass and high charge density that distinguish the neurofilament proteins from all other intermediate filament proteins are due to the tailpiece extensions. This region may form a charged scaffolding structure suitable for interaction with other neuronal components or ions.PTM O-glycosylated.PTM Phosphorylated in the head and rod regions by the PKC kinase PKN1, leading to the inhibition of polymerization.PTM Ubiquitinated in the presence of TRIM2 and UBE2D1.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS NF-L is the most abundant of the three neurofilament proteins and, like the other nonepithelial intermediate filament proteins, it can form homomeric 10-nm filaments.SIMILARITY Belongs to the intermediate filament family. |
| description | recommendedName: Neurofilament light polypeptide shortName: NF-L alternativeName: 68 kDa neurofilament protein alternativeName: Neurofilament triplet L protein |
| geneName | NEFL NF68 NFL |
| identifier | P07196 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cell projection Charcot-Marie-Tooth disease Coiled coil Cytoplasm Cytoskeleton Direct protein sequencing Disease variant Glycoprotein Intermediate filament Methylation Neurodegeneration Neuropathy Phosphoprotein Proteomics identification Reference proteome Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | NEFL |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8993176] ENSEMBL:ENSG00000277586 NEFL [Homo sapiens] |
| secondaryIdentifier | NFL_HUMAN B9ZVN2 Q16154 Q8IU72 |
| sequenceLength | 543 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:432284] NEFL [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P07196 NEFL (60147)
