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Details on Person UniProt:P08949 NMB
| Class:Id | ReferenceGeneProduct:60093 |
|---|---|
| _chainChangeLog | signal peptide:1-24 added on Fri February 6 2015;peptide:25-56 added on Fri February 6 2015;peptide:47-56 added on Fri February 6 2015;propeptide:60-121 added on Fri February 6 2015 |
| _displayName | UniProt:P08949 NMB |
| _timestamp | 2024-11-03 19:37:48 |
| chain | signal peptide:1-24 peptide:25-56 peptide:47-56 propeptide:60-121 |
| checksum | 10E16BA4886F03FB |
| comment | FUNCTION Stimulates smooth muscle contraction (By similarity). Induces sighing by acting directly on the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through activation of the NMBR receptor on dorsal root ganglion neurons (By similarity). Increases expression of NMBR and steroidogenic mediators STAR, CYP11A1 and HSD3B1 in Leydig cells, induces secretion of testosterone by Leydig cells and also promotes Leydig cell proliferation (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity).INTERACTION In neurons of the retrotrapezoid nucleus//parafacial respiratory group, expressed on neuron projections which project into the pre-Botzinger complex.ALTERNATIVE PRODUCTS Up-regulated in response to infection with influenza A virus.SIMILARITY Belongs to the bombesin/neuromedin-B/ranatensin family. |
| description | recommendedName: Neuromedin-B component recommendedName: Neuromedin-B-32 /component component recommendedName: Neuromedin-B /component |
| geneName | NMB |
| identifier | P08949 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Amidation Cell projection Cleavage on pair of basic residues Immunity Innate immunity Proteomics identification Reference proteome Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NMB |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9002500] ENSEMBL:ENSG00000197696 NMB [Homo sapiens] |
| secondaryIdentifier | NMB_HUMAN Q96A06 Q96HH5 |
| sequenceLength | 121 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:150950] UniProt:P08949-2 NMB [Homo sapiens] [ReferenceIsoform:402633] UniProt:P08949-1 NMB [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:375361] NMB(47-56) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P08949 NMB (60093)
