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Details on Person UniProt:P01185 AVP
| Class:Id | ReferenceGeneProduct:60091 |
|---|---|
| _chainChangeLog | signal peptide:1-19 added on Fri February 6 2015;peptide:20-28 added on Fri February 6 2015;chain:32-124 added on Fri February 6 2015;peptide:126-164 added on Fri February 6 2015 |
| _displayName | UniProt:P01185 AVP |
| _timestamp | 2026-02-20 22:35:31 |
| chain | signal peptide:1-19 peptide:20-28 chain:32-124 peptide:126-164 |
| checksum | 8F5EF9834700B9AE |
| comment | FUNCTION Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2).FUNCTION Specifically binds vasopressin.SUBUNIT Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (PubMed:18174156). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (PubMed:18174156).SUBUNIT (Microbial infection) May interact with SARS coronavirus-2/SARS-CoV-2; they may form a complex with secreted ACE2.INTERACTION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the vasopressin/oxytocin family.ONLINE INFORMATION Vasopressin entry |
| description | recommendedName: Vasopressin-neurophysin 2-copeptin alternativeName: AVP-NPII component recommendedName: Arg-vasopressin alternativeName: Arginine-vasopressin /component component recommendedName: Neurophysin 2 alternativeName: Neurophysin-II /component component recommendedName: Copeptin /component |
| geneName | AVP ARVP VP |
| identifier | P01185 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Amidation Cleavage on pair of basic residues Diabetes insipidus Direct protein sequencing Disease variant Disulfide bond Glycoprotein Hormone Host-virus interaction Proteomics identification Reference proteome Secreted Signal Vasoactive Vasoconstrictor |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | AVP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5641213] ENSEMBL:ENSG00000101200 AVP [Homo sapiens] |
| secondaryIdentifier | NEU2_HUMAN A0AV35 O14935 |
| sequenceLength | 164 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:388474] AVP(20-28) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:879509] AVP(20-28) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5621396] AVP E47del [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5621431] AVP C67* [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5621446] AVP V67A [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5621449] AVP Y2H [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5621460] AVP P7L [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5621464] AVP G23R [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:5621473] AVP A1T [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8869075] AVP(20-28) [clathrin-coated endocytic vesicle membrane] [Homo sapiens] |
| (referenceSequence) | [FragmentDeletionModification:5621389] Deletion of residues 47 to 47 [ReplacedResidue:5621390] glycine 23 replaced with L-arginine [NonsenseMutation:5621400] Nonsense mutation at L-cysteine 67 [ReplacedResidue:5621462] L-alanine 1 replaced with L-threonine [ReplacedResidue:5621463] L-valine 67 replaced with L-alanine [ReplacedResidue:5621472] L-proline 7 replaced with L-leucine [ReplacedResidue:5621475] L-tyrosine 2 replaced with L-histidine |
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No pathways have been reviewed or authored by UniProt:P01185 AVP (60091)
