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Details on Person UniProt:P08473 MME
| Class:Id | ReferenceGeneProduct:60073 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-750 added on Fri February 6 2015;initiator methionine:1 for 60073 removed on Fri Nov 03 2023;initiator methionine: for 60073 added on Fri Nov 03 2023;initiator methionine: for 60073 removed on Fri Aug 15 2025;initiator methionine:1 for 60073 added on Fri Aug 15 2025 |
| _displayName | UniProt:P08473 MME |
| _timestamp | 2025-08-15 21:01:36 |
| chain | initiator methionine:1 chain:2-750 |
| checksum | BCF3827C39898630 |
| comment | FUNCTION Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:6208535, PubMed:6349683, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991, PubMed:6349683). Catalyzes cleavage of bradykinin, substance P and neurotensin peptides (PubMed:6208535). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675, PubMed:6349683). Involved in the degradation of atrial natriuretic factor (ANF) and brain natriuretic factor (BNP(1-32)) (PubMed:16254193, PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573).CATALYTIC ACTIVITY Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.CATALYTIC ACTIVITY substance P + H2O = substance P(1-9) + L-Leu-L-Met-NH2CATALYTIC ACTIVITY substance P + H2O = substance P(1-7) + L-Phe-Gly-L-Leu-L-Met-NH2CATALYTIC ACTIVITY neurotensin + H2O = neurotensin(1-11) + L-isoleucyl-L-leucineCATALYTIC ACTIVITY neurotensin + H2O = neurotensin(1-10) + L-tyrosyl-L-isoleucyl-L-leucineCOFACTOR Binds 1 zinc ion per subunit.ACTIVITY REGULATION Inhibited in a dose dependent manner by opiorphin (PubMed:17101991). Activated by K49-P1-20, a twenty-residue synthetic peptide shortened from the snake B.asper myotoxin II (PubMed:26931059).BIOPHYSICOCHEMICAL PROPERTIES Myristoylation is a determinant of membrane targeting.PTM Glycosylation at Asn-628 is necessary both for surface expression and neutral endopeptidase activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.MISCELLANEOUS Important cell surface marker in the diagnostic of human acute lymphocytic leukemia.SIMILARITY Belongs to the peptidase M13 family.SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: fullName evidence="27"Neprilysin ecNumber evidence="9 20 24 25 26"3.4.24.11 alternativeName: Atriopeptidase alternativeName: Common acute lymphocytic leukemia antigen shortName: CALLA alternativeName: fullName evidence="31"Enkephalinase alternativeName: fullName evidence="29"Neutral endopeptidase 24.11 shortName: NEP shortName: Neutral endopeptidase alternativeName: Skin fibroblast elastase shortName: SFE cdAntigenName evidence="28"CD10/cdAntigenName |
| geneName | MME EPN |
| identifier | P08473 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cell membrane Charcot-Marie-Tooth disease Disease variant Disulfide bond Glycoprotein Hydrolase Lipoprotein Membrane Metal-binding Metalloprotease Myristate Neurodegeneration Neuropathy Phosphoprotein Protease Proteomics identification Reference proteome Signal-anchor Spinocerebellar ataxia Transmembrane Transmembrane helix Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MME |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989658] ENSEMBL:ENSG00000196549 MME [Homo sapiens] |
| secondaryIdentifier | NEP_HUMAN A8K6U6 D3DNJ9 Q3MIX4 |
| sequenceLength | 750 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:2022342] MME [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806156] MME [secretory granule membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P08473 MME (60073)
