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Details on Person UniProt:Q92597 NDRG1

Class:Id	ReferenceGeneProduct:60031
_chainChangeLog	initiator methionine:1 added on Fri February 6 2015;chain:2-394 added on Fri February 6 2015;initiator methionine:1 for 60031 removed on Fri Nov 03 2023;initiator methionine: for 60031 added on Fri Nov 03 2023;initiator methionine: for 60031 removed on Fri Aug 15 2025;initiator methionine:1 for 60031 added on Fri Aug 15 2025
_displayName	UniProt:Q92597 NDRG1
_timestamp	2025-08-15 22:02:16
chain	initiator methionine:1 chain:2-394
checksum	4C816B9C85E3756F
comment	FUNCTION Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle checkpoint. Regulates microtubule dynamics and maintains euploidy.SUBUNIT Interacts with RAB4A (membrane-bound form); the interaction involves NDRG1 in vesicular recycling of CDH1.INTERACTION Mainly cytoplasmic but differentially localized to other regions. Associates with the plasma membrane in intestinal epithelia and lactating mammary gland. Translocated to the nucleus in a p53/TP53-dependent manner. In prostate epithelium and placental chorion, located in both the cytoplasm and in the nucleus. No nuclear localization in colon epithelium cells. In intestinal mucosa, prostate and renal cortex, located predominantly adjacent to adherens junctions. Cytoplasmic with granular staining in proximal tubular cells of the kidney and salivary gland ducts. Recruits to the membrane of recycling/sorting and late endosomes via binding to phosphatidylinositol 4-phosphate. Associates with microtubules. Colocalizes with TUBG1 in the centrosome. Cytoplasmic location increased with hypoxia. Phosphorylated form found associated with centromeres during S-phase of mitosis and with the plasma membrane.ALTERNATIVE PRODUCTS Ubiquitous; expressed most prominently in placental membranes and prostate, kidney, small intestine, and ovary tissues. Also expressed in heart, brain, skeletal muscle, lung, liver and pancreas. Low levels in peripheral blood leukocytes and in tissues of the immune system. Expressed mainly in epithelial cells. Also found in Schwann cells of peripheral neurons. Reduced expression in adenocarcinomas compared to normal tissues. In colon, prostate and placental membranes, the cells that border the lumen show the highest expression.INDUCTION By homocysteine, 2-mercaptoethanol, tunicamycin in endothelial cells. Induced approximately 20-fold during in vitro differentiation of the colon carcinoma cell lines HT-29-D4 and Caco-2. Induced by oxidative stress in colon cancers. Decreased expression in colon adenomas and adenocarcinomas. Induced by nickel compounds in all tested cell lines. The primary signal for its induction is an elevation of free intracellular calcium ion caused by nickel ion exposure. Okadaic acid, a serine/threonine phosphatase inhibitor, induced its expression more rapidly and more efficiently than nickel.PTM Under stress conditions, phosphorylated in the C-terminal on many serine and threonine residues. Phosphorylated in vitro by PKA. Phosphorylation enhanced by increased intracellular cAMP levels. Homocysteine induces dephosphorylation. Phosphorylation by SGK1 is cell cycle dependent.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the NDRG family.
description	recommendedName: Protein NDRG1 alternativeName: Differentiation-related gene 1 protein shortName: DRG-1 alternativeName: N-myc downstream-regulated gene 1 protein alternativeName: Nickel-specific induction protein Cap43 alternativeName: Reducing agents and tunicamycin-responsive protein shortName: RTP alternativeName: Rit42
geneName	NDRG1 CAP43 DRG1 RTP
identifier	Q92597
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Alternative splicing Cell membrane Charcot-Marie-Tooth disease Cytoplasm Cytoskeleton Direct protein sequencing Membrane Microtubule Neurodegeneration Neuropathy Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	NDRG1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:5628851] ENSEMBL:ENSG00000104419 NDRG1 [Homo sapiens]
secondaryIdentifier	NDRG1_HUMAN B3KR80 B7Z446 O15207 Q6IBG2 Q9NYR6 Q9UK29
sequenceLength	394
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:8965707] UniProt:Q92597-1 NDRG1 [Homo sapiens] [ReferenceIsoform:8965708] UniProt:Q92597-2 NDRG1 [Homo sapiens] [ReferenceIsoform:8965709] UniProt:Q92597-3 NDRG1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:5628834] NDRG1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9988587] NDRG1 [nucleoplasm] [Homo sapiens]
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No pathways have been reviewed or authored by UniProt:Q92597 NDRG1 (60031)