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Details on Person UniProt:P01213 PDYN
| Class:Id | ReferenceGeneProduct:60003 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Fri February 6 2015;propeptide:21-172 added on Fri February 6 2015;peptide:175-184 added on Fri February 6 2015;peptide:175-183 added on Fri February 6 2015;peptide:175-179 added on Fri February 6 2015;propeptide:186-204 added on Fri February 6 2015;peptide:207-238 added on Fri February 6 2015;peptide:207-223 added on Fri February 6 2015;peptide:207-219 added on Fri February 6 2015;peptide:207-214 added on Fri February 6 2015;peptide:207-211 added on Fri February 6 2015;peptide:226-254 added on Fri February 6 2015;peptide:226-238 added on Fri February 6 2015;peptide:226-230 added on Fri February 6 2015 |
| _displayName | UniProt:P01213 PDYN |
| _timestamp | 2024-11-03 20:15:55 |
| chain | signal peptide:1-20 propeptide:21-172 peptide:175-184 peptide:175-183 peptide:175-179 propeptide:186-204 peptide:207-238 peptide:207-223 peptide:207-219 peptide:207-214 peptide:207-211 peptide:226-254 peptide:226-238 peptide:226-230 |
| checksum | 783E7D6AC068CE68 |
| comment | FUNCTION Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity).FUNCTION Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opioid activity, it is 700 times more potent than Leu-enkephalin (By similarity).FUNCTION Leumorphin has a typical opioid activity and may have anti-apoptotic effect.INTERACTION The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the opioid neuropeptide precursor family. |
| description | recommendedName: Proenkephalin-B alternativeName: Beta-neoendorphin-dynorphin alternativeName: Preprodynorphin component recommendedName: Alpha-neoendorphin /component component recommendedName: Beta-neoendorphin /component component recommendedName: Big dynorphin shortName: Big Dyn /component component recommendedName: Dynorphin A(1-17) shortName: Dyn-A17 shortName: Dynorphin A /component component recommendedName: Dynorphin A(1-13) /component component recommendedName: Dynorphin A(1-8) /component component recommendedName: Leu-enkephalin /component component recommendedName: Rimorphin alternativeName: Dynorphin B shortName: Dyn-B alternativeName: Dynorphin B(1-13) /component component recommendedName: Leumorphin alternativeName: Dynorphin B-29 /component |
| geneName | PDYN |
| identifier | P01213 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Cleavage on pair of basic residues Disease variant Disulfide bond Endorphin Neurodegeneration Neuropeptide Neurotransmitter Opioid peptide Proteomics identification Reference proteome Secreted Signal Spinocerebellar ataxia |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | PDYN |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996784] ENSEMBL:ENSG00000101327 PDYN [Homo sapiens] |
| secondaryIdentifier | PDYN_HUMAN A8K0Q3 |
| sequenceLength | 254 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:167437] PDYN(226-230) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:374378] PDYN(175-184) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:374380] PDYN(207-238) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:374383] PDYN(226-238) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:374387] PDYN(175-183) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:374388] PDYN(207-223) [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P01213 PDYN (60003)
