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Details on Person UniProt:Q93070 ART4
| Class:Id | ReferenceGeneProduct:59919 |
|---|---|
| _chainChangeLog | signal peptide:1-46 added on Sat February 7 2015;chain:47-285 added on Sat February 7 2015;propeptide:286-314 added on Sat February 7 2015 |
| _displayName | UniProt:Q93070 ART4 |
| _timestamp | 2025-08-15 21:09:01 |
| chain | signal peptide:1-46 chain:47-285 propeptide:286-314 |
| checksum | 1744A8E4B7FD158F |
| comment | CATALYTIC ACTIVITY L-arginyl-[protein] + NAD(+) = N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide + H(+)SUBCELLULAR LOCATION Expressed in spleen and T-cells.POLYMORPHISM Variations in the ART4 gene are the basis of the Dombrock blood group system (Do). ART4 carries two antithetical antigens (Do(a) and Do(b)) and 3 high-incidence antigens, Gregory (Gy(a)), Holley (Hy), and Joseph (Jo(a)). Do(a) and Do(b) differ by a single variation at position 265, with Asn-265 corresponding to Do(a) and Asp-265 (shown in this entry) to Do(b).SIMILARITY Belongs to the Arg-specific ADP-ribosyltransferase family. |
| description | recommendedName: Ecto-ADP-ribosyltransferase 4 ecNumber: 2.4.2.31 alternativeName: ADP-ribosyltransferase C2 and C3 toxin-like 4 shortName: ARTC4 alternativeName: Dombrock blood group carrier molecule alternativeName: Mono(ADP-ribosyl)transferase 4 alternativeName: NAD(P)(+)--arginine ADP-ribosyltransferase 4 cdAntigenNameCD297/cdAntigenName |
| geneName | ART4 DO DOK1 |
| identifier | Q93070 |
| isSequenceChanged | FALSE |
| keyword | Blood group antigen Cell membrane Disulfide bond Glycoprotein Glycosyltransferase GPI-anchor Lipoprotein Membrane NAD NADP Nucleotidyltransferase Proteomics identification Reference proteome Signal Transferase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9862192] Weiser, Joel, 2024-02-26 [InstanceEdit:9909836] Weiser, Joel, 2024-05-14 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | ART4 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989652] ENSEMBL:ENSG00000111339 ART4 [Homo sapiens] |
| secondaryIdentifier | NAR4_HUMAN Q9BZ50 Q9BZ51 Q9HB06 |
| sequenceLength | 314 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:8940433] ART4 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8940722] GPI-ART4 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8941009] cleaved GPI-ART4 [extracellular region] [Homo sapiens] |
| (referenceSequence) | [GroupModifiedResidue:8940780] L-alanine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 285 [GroupModifiedResidue:8941080] L-alanine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 285 [GroupModifiedResidue:8941226] unknown (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q93070 ART4 (59919)
