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Details on Person UniProt:Q14940 SLC9A5
| Class:Id | ReferenceGeneProduct:59897 |
|---|---|
| _chainChangeLog | chain:1-896 added on Sat February 7 2015 |
| _displayName | UniProt:Q14940 SLC9A5 |
| _timestamp | 2025-02-21 19:22:56 |
| chain | chain:1-896 |
| checksum | B9D234BFE0922269 |
| comment | FUNCTION Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, thus regulating intracellular pH homeostasis, in particular in neural tissues (PubMed:10692428, PubMed:19276089, PubMed:24936055, PubMed:9933641). Acts as a negative regulator of dendritic spine growth (PubMed:21551074). Plays a role in postsynaptic remodeling and signaling (PubMed:21551074, PubMed:24006492). Can also contribute to organellar pH regulation, with consequences for receptor tyrosine kinase trafficking (PubMed:24936055).CATALYTIC ACTIVITY Na(+)(in) + H(+)(out) = Na(+)(out) + H(+)(in)ACTIVITY REGULATION ATP-depletion almost completely abolishes SLC9A5 activity. Inhibited by amiloride compounds.SUBUNIT Interacts with CHP1 and CHP2 (By similarity). Interacts with ARRB2; facilitates the endocytosis of SLC9A5 from the plasma membrane (PubMed:15699339, PubMed:21296876). Interacts with RACK1; this interaction positively regulates SLC9A5 activity and promotes SLC9A5 localization to focal adhesions (PubMed:24006492). Interacts with SCAMP2; this interaction regulates SLC9A5 cell-surface targeting and SLC9A5 activity (PubMed:19276089).SUBCELLULAR LOCATION Cycles between recycling endosome and plasma membrane in response to diverse stimuli. Its internalization is clathrin- and beta-arrestin dependent and its plasma membrane insertion from the recycling endosomes requires phosphoinositide 3-kinase (PIK3CA) and SCAMP2.TISSUE SPECIFICITY Mainly expressed in brain (PubMed:7759094, PubMed:9933641). Expressed in neurons of the central and peripheral nervous system (PubMed:21551074, PubMed:9933641). Expressed also in testis, spleen, and skeletal muscle (PubMed:7759094).PTM Phosphorylated by PRKAA2; promotes its accumulation at the cell surface (PubMed:24936055). Phosphorylated by CSNK2A1 in a manner favoring its beta-arrestin binding and endocytosis (PubMed:21296876).SIMILARITY Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. |
| description | recommendedName: Sodium/hydrogen exchanger 5 alternativeName: Na(+)/H(+) exchanger 5 shortName: NHE-5 alternativeName: Solute carrier family 9 member 5 |
| geneName | SLC9A5 NHE5 |
| identifier | Q14940 |
| isSequenceChanged | FALSE |
| keyword | Antiport Cell junction Cell membrane Cell projection Endosome Glycoprotein Ion transport Membrane Phosphoprotein Postsynaptic cell membrane Proteomics identification Reference proteome Sodium Sodium transport Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC9A5 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996874] ENSEMBL:ENSG00000135740 SLC9A5 [Homo sapiens] |
| secondaryIdentifier | SL9A5_HUMAN A5PKY7 Q9Y626 |
| sequenceLength | 896 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:425989] SLC9A5 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q14940 SLC9A5 (59897)
