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Details on Person UniProt:Q9UBY0 SLC9A2
| Class:Id | ReferenceGeneProduct:59893 |
|---|---|
| _chainChangeLog | chain:1-812 added on Sat February 7 2015 |
| _displayName | UniProt:Q9UBY0 SLC9A2 |
| _timestamp | 2025-02-21 19:54:08 |
| chain | chain:1-812 |
| checksum | 17EE177DC3830D0A |
| comment | FUNCTION Plasma membrane Na(+)/H(+) antiporter. Mediates the electroneutral exchange of intracellular H(+) ions for extracellular Na(+) (PubMed:10444453). Major apical Na(+)/H(+) exchanger in the base of the colonic crypt. Controls in the colonic crypt intracellular pH (pHi) to direct colonic epithelial cell differentiation into the absorptive enterocyte lineage at the expense of the secretory lineage (By similarity).CATALYTIC ACTIVITY Na(+)(in) + H(+)(out) = Na(+)(out) + H(+)(in)SUBUNIT Interacts with CHP1 and CHP2.SUBCELLULAR LOCATION Expressed in skeletal muscle, colon and kidney. Lower levels in the testis, prostate, ovary, and small intestine (PubMed:10444453, PubMed:8843774). In the distal colon, expressed along the cryptal axis (PubMed:8843774).SIMILARITY Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.CAUTION The number, localization and denomination of hydrophobic domains in the Na(+)/H(+) exchangers vary among authors. |
| description | recommendedName: Sodium/hydrogen exchanger 2 alternativeName: Na(+)/H(+) exchanger 2 shortName: NHE-2 alternativeName: Solute carrier family 9 member 2 |
| geneName | SLC9A2 NHE2 |
| identifier | Q9UBY0 |
| isSequenceChanged | FALSE |
| keyword | Antiport Cell membrane Glycoprotein Ion transport Membrane Phosphoprotein Proteomics identification Reference proteome Sodium Sodium transport Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | SLC9A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999154] ENSEMBL:ENSG00000115616 SLC9A2 [Homo sapiens] |
| secondaryIdentifier | SL9A2_HUMAN B2RMS2 |
| sequenceLength | 812 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:425975] SLC9A2 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9UBY0 SLC9A2 (59893)
