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Details on Person UniProt:Q9UPR5 SLC8A2
| Class:Id | ReferenceGeneProduct:59875 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Fri February 6 2015;chain:21-921 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UPR5 SLC8A2 |
| _timestamp | 2024-08-09 19:23:12 |
| chain | signal peptide:1-20 chain:21-921 |
| checksum | 798CDF7E32B9410C |
| comment | FUNCTION Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells. Contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory. Plays a role in regulating urinary Ca(2+) and Na(+) excretion.CATALYTIC ACTIVITY Ca(2+)(in) + 3 Na(+)(out) = Ca(2+)(out) + 3 Na(+)(in)ACTIVITY REGULATION Calcium transport is down-regulated by Na(+) and stimulated by Ca(2+).SUBCELLULAR LOCATION The cytoplasmic Calx-beta domains bind the regulatory Ca(2+). The first Calx-beta domain can bind up to four Ca(2+) ions. The second domain can bind another two Ca(2+) ions that are essential for calcium-regulated ion exchange.SIMILARITY Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily. |
| description | recommendedName: Sodium/calcium exchanger 2 alternativeName: Na(+)/Ca(2+)-exchange protein 2 alternativeName: Solute carrier family 8 member 2 |
| geneName | SLC8A2 KIAA1087 NCX2 |
| identifier | Q9UPR5 |
| isSequenceChanged | FALSE |
| keyword | Antiport Calcium Calcium transport Calmodulin-binding Cell membrane Cell projection Glycoprotein Ion transport Membrane Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Signal Sodium Sodium transport Synapse Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 |
| name | SLC8A2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992605] ENSEMBL:ENSG00000118160 SLC8A2 [Homo sapiens] |
| secondaryIdentifier | NAC2_HUMAN B4DYQ9 |
| sequenceLength | 921 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:425656] SLC8A2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9UPR5 SLC8A2 (59875)
