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Details on Person UniProt:Q15742 NAB2
| Class:Id | ReferenceGeneProduct:59871 |
|---|---|
| _chainChangeLog | chain:1-525 added on Fri February 6 2015 |
| _displayName | UniProt:Q15742 NAB2 |
| _timestamp | 2024-11-03 19:47:12 |
| chain | chain:1-525 |
| checksum | 38CF6CFEFE3756F9 |
| comment | FUNCTION Acts as a transcriptional repressor for zinc finger transcription factors EGR1 and EGR2. Isoform 2 lacks repression ability (By similarity).SUBUNIT Homomultimers may associate with EGR1 bound to DNA.INTERACTION Isoform 2 is not localized to the nucleus.ALTERNATIVE PRODUCTS Widely expressed at low levels. Highly expressed in melanoma cell lines.INDUCTION By serum and phorbol myristate acetate (PMA) stimulation.DOMAIN The NAB conserved domain 1 (NCD1) interacts with EGR1 inhibitory domain and mediates multimerization.DOMAIN The NAB conserved domain 2 (NCD2) is necessary for transcriptional repression.PTM Sumoylation by EGR2 represses EGR2 transcriptional activity in hindbrain.SIMILARITY Belongs to the NAB family. |
| description | recommendedName: NGFI-A-binding protein 2 alternativeName: EGR-1-binding protein 2 alternativeName: Melanoma-associated delayed early response protein shortName: Protein MADER |
| geneName | NAB2 MADER |
| identifier | Q15742 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Isopeptide bond Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NAB2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8962465] ENSEMBL:ENSG00000166886 NAB2 [Homo sapiens] |
| secondaryIdentifier | NAB2_HUMAN B2RAK3 O76006 Q14797 |
| sequenceLength | 525 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:150823] UniProt:Q15742-2 NAB2 [Homo sapiens] [ReferenceIsoform:150824] UniProt:Q15742-3 NAB2 [Homo sapiens] [ReferenceIsoform:405885] UniProt:Q15742-1 NAB2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9612177] NAB2 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q15742 NAB2 (59871)
