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Details on Person UniProt:Q9ULX6 AKAP8L
| Class:Id | ReferenceGeneProduct:59867 |
|---|---|
| _chainChangeLog | chain:1-646 added on Sat February 7 2015 |
| _displayName | UniProt:Q9ULX6 AKAP8L |
| _timestamp | 2024-11-03 19:34:58 |
| chain | chain:1-646 |
| checksum | CBC265BF25996BA2 |
| comment | FUNCTION Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903).FUNCTION (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters.FUNCTION (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses.FUNCTION (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity.SUBUNIT Interacts (via N-terminus) with DHX9 (via RGG region) (PubMed:10748171, PubMed:11402034). Interacts with TMPO isoform Beta, PRPF40A, RNF43, lamin-B (PubMed:11034899, PubMed:12538639, PubMed:16391387, PubMed:18313049). Interacts with HDAC3; increased during mitosis (PubMed:16980585). Interacts with EBV EBNA-LP (PubMed:11160753). Interacts with HIV-1 reverse transcriptase/ribonuclease H (PubMed:25034436).INTERACTION Colocalizes with PRPF40A in the nuclear matrix (PubMed:16391387). Nuclear at steady state but shuttles between the nucleus and cytoplasm (PubMed:10748171). The shuttling property has been questioned (PubMed:11034899). Colocalizes with EBNA-LP in PML bodies (PubMed:11884601).ALTERNATIVE PRODUCTS Ubiquitously expressed. Expressed in the brain cortex (at protein level).PTM Phosphorylated on serine or threonine residues possibly by PKA; probably modulating the interaction with TMPO isoform Beta.SIMILARITY Belongs to the AKAP95 family.SEQUENCE CAUTION Extended N-terminus. |
| description | recommendedName: A-kinase anchor protein 8-like shortName: AKAP8-like protein alternativeName: Helicase A-binding protein 95 shortName: HAP95 alternativeName: Homologous to AKAP95 protein shortName: HA95 alternativeName: Neighbor of A-kinase-anchoring protein 95 shortName: Neighbor of AKAP95 |
| geneName | AKAP8L NAKAP NAKAP95 HRIHFB2018 |
| identifier | Q9ULX6 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Cytoplasm Host-virus interaction Metal-binding Methylation mRNA processing mRNA splicing Nucleus Phosphoprotein Proteomics identification Reference proteome Repeat Transcription Transcription regulation Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | AKAP8L |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8992880] ENSEMBL:ENSG00000011243 AKAP8L [Homo sapiens] |
| secondaryIdentifier | AKP8L_HUMAN B4DJ74 B5BU90 O94792 Q96J58 Q9NRQ0 Q9UGM0 |
| sequenceLength | 646 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8977283] UniProt:Q9ULX6-1 AKAP8L [Homo sapiens] [ReferenceIsoform:8977284] UniProt:Q9ULX6-2 AKAP8L [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:9821364] AKAP8L [nucleoplasm] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:Q9ULX6 AKAP8L (59867)
