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Details on Person UniProt:O95298 NDUFC2
| Class:Id | ReferenceGeneProduct:59861 |
|---|---|
| _chainChangeLog | chain:1-119 added on Sat February 7 2015 |
| _displayName | UniProt:O95298 NDUFC2 |
| _timestamp | 2024-11-03 19:42:09 |
| chain | chain:1-119 |
| checksum | 9A47DEE33DC9244D |
| comment | FUNCTION Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis but required for the complex assembly. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.SUBUNIT Complex I is composed of 45 different subunits. Interacts with TMEM242 (PubMed:33753518).SUBCELLULAR LOCATION The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the complex I NDUFC2 subunit family. |
| description | recommendedName: fullName evidence="10"NADH dehydrogenase [ubiquinone] 1 subunit C2 alternativeName: Complex I-B14.5b shortName: CI-B14.5b alternativeName: Human lung cancer oncogene 1 protein shortName: HLC-1 alternativeName: NADH-ubiquinone oxidoreductase subunit B14.5b |
| geneName | NDUFC2 HLC1 |
| identifier | O95298 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disease variant Electron transport Membrane Mitochondrion Mitochondrion inner membrane Primary mitochondrial disease Proteomics identification Reference proteome Respiratory chain Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | NDUFC2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:9001918] ENSEMBL:ENSG00000151366 NDUFC2 [Homo sapiens] |
| secondaryIdentifier | NDUC2_HUMAN E9PNU8 E9PRB2 Q549M5 Q6FIH8 Q9UBJ9 |
| sequenceLength | 119 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975222] UniProt:O95298-1 NDUFC2 [Homo sapiens] [ReferenceIsoform:8975223] UniProt:O95298-2 NDUFC2 [Homo sapiens] [ReferenceIsoform:8975224] UniProt:O95298-3 NDUFC2 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:59860] NDUFC2 [mitochondrial inner membrane] [Homo sapiens] [EntityWithAccessionedSequence:6799211] NDUFC2 [azurophil granule membrane] [Homo sapiens] [EntityWithAccessionedSequence:6806276] NDUFC2 [plasma membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:O95298 NDUFC2 (59861)
