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Details on Person UniProt:P15172 MYOD1

Class:IdReferenceGeneProduct:59819
_chainChangeLogchain:1-320 added on Fri February 6 2015
_displayNameUniProt:P15172 MYOD1
_timestamp2024-11-03 20:15:26
chainchain:1-320
checksum75E624D2ED5B0B33
commentFUNCTION Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Together with MYF5 and MYOG, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).SUBUNIT Efficient DNA binding requires dimerization with another bHLH protein. Seems to form active heterodimers with ITF-2. Interacts with SUV39H1. Interacts with DDX5. Interacts with CHD2. Interacts with TSC22D3 (By similarity). Interacts with SETD3 (By similarity). Interacts with P-TEFB complex; promotes the transcriptional activity of MYOD1 through its CDK9-mediated phosphorylation (By similarity) (PubMed:12037670). Interacts with CSRP3. Interacts with NUPR1 (By similarity).INTERACTION Phosphorylated by CDK9. This phosphorylation promotes its function in muscle differentiation.PTM Acetylated by a complex containing EP300 and PCAF. The acetylation is essential to activate target genes. Conversely, its deacetylation by SIRT1 inhibits its function (By similarity).PTM Ubiquitinated on the N-terminus; which is required for proteasomal degradation.PTM Methylation at Lys-104 by EHMT2/G9a inhibits myogenic activity.DISEASE The disease is caused by variants affecting the gene represented in this entry.ONLINE INFORMATION MyoD entry
descriptionrecommendedName: Myoblast determination protein 1 alternativeName: Class C basic helix-loop-helix protein 1 shortName: bHLHc1 alternativeName: Myogenic factor 3 shortName: Myf-3
geneNameMYOD1
BHLHC1
MYF3
MYOD
identifierP15172
isSequenceChangedFALSE
keywordAcetylation
Activator
Developmental protein
Differentiation
Disease variant
DNA-binding
Methylation
Myogenesis
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transcription
Transcription regulation
Ubl conjugation
modified[InstanceEdit:9836292] Weiser, Joel, 2023-05-25
[InstanceEdit:9852000] Weiser, Joel, 2023-11-03
[InstanceEdit:9926675] Weiser, Joel, 2024-11-03
nameMYOD1
referenceDatabase[ReferenceDatabase:2] UniProt
referenceGene[ReferenceDNASequence:8990840] ENSEMBL:ENSG00000129152 MYOD1 [Homo sapiens]
secondaryIdentifierMYOD1_HUMAN
O75321
sequenceLength320
species[Species:48887] Homo sapiens
(referenceEntity)[EntityWithAccessionedSequence:264449] MYOD1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:445441] MYOD1 [nucleoplasm] [Homo sapiens]
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