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Details on Person UniProt:P11055 MYH3
| Class:Id | ReferenceGeneProduct:59789 |
|---|---|
| _chainChangeLog | chain:1-1940 added on Sat February 7 2015 |
| _displayName | UniProt:P11055 MYH3 |
| _timestamp | 2024-11-03 20:01:59 |
| chain | chain:1-1940 |
| checksum | B7D6AF219E88E5C8 |
| comment | FUNCTION Muscle contraction.SUBUNIT Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2).SUBCELLULAR LOCATION Thick filaments of the myofibrils.TISSUE SPECIFICITY Expressed in fetal bone, thymus, placenta, heart, brain, and liver.DEVELOPMENTAL STAGE Abundantly present in fetal skeletal muscle and not present or barely detectable in heart and adult skeletal muscle.DOMAIN The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.DOMAIN Limited proteolysis of myosin heavy chain produces 1 light meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment (S2).DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.CAUTION Represents a conventional myosin. This protein should not be confused with the unconventional myosin-3 (MYO3).CAUTION Variants Ala-1622 and Val-1637 have been originally reported as DA2B3 pathogenic mutations (PubMed:16642020). These variants are now thought to be polymorphisms on the basis of additional family information and frequencies in large databases of control populations (PubMed:25957469). |
| description | recommendedName: Myosin-3 alternativeName: Muscle embryonic myosin heavy chain alternativeName: Myosin heavy chain 3 alternativeName: Myosin heavy chain, fast skeletal muscle, embryonic alternativeName: SMHCE |
| geneName | MYH3 |
| identifier | P11055 |
| isSequenceChanged | FALSE |
| keyword | Actin-binding ATP-binding Calmodulin-binding Coiled coil Cytoplasm Disease variant Methylation Motor protein Muscle protein Myosin Nucleotide-binding Proteomics identification Reference proteome Thick filament |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MYH3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994360] ENSEMBL:ENSG00000109063 MYH3 [Homo sapiens] |
| secondaryIdentifier | MYH3_HUMAN Q15492 |
| sequenceLength | 1940 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:390560] MYH3 [cytosol] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:P11055 MYH3 (59789)
