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Details on Person UniProt:Q9HC84 MUC5B
| Class:Id | ReferenceGeneProduct:59699 |
|---|---|
| _chainChangeLog | signal peptide:1-25 added on Sat February 7 2015;chain:26-5762 added on Sat February 7 2015 |
| _displayName | UniProt:Q9HC84 MUC5B |
| _timestamp | 2024-11-03 20:06:22 |
| chain | signal peptide:1-25 chain:26-5762 |
| checksum | 1FEC7CDCD0ADA81C |
| comment | FUNCTION Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.SUBUNIT Homomultimer; disulfide-linked (PubMed:31570524). The N- and C-terminus mediate their assembly into higher order structures to form filaments (By similarity). The CTCK domains of two polypeptides associate in the endoplasmic reticulum to generate intermolecularly disulfide-bonded dimers (PubMed:31570524). These dimers progress to the Golgi apparatus, which is a more acidic environment than the endoplasmic reticulum (By similarity). Under acidic conditions, the N-termini form non-covalent intermolecular interactions that juxtapose assemblies from different CTCK-linked dimers to produce long, disulfide-linked polymers that remain highly compact until secretion (By similarity).SUBCELLULAR LOCATION Expressed on surface airway epithelia. Expressed mainly in mucous cells of submucosal glands of airway tissues. Highly expressed in the sublingual gland. Also found in submaxillary glands, endocervix, gall bladder, and pancreas.INDUCTION Regulated by all-trans-retinoic acid (ATRA) in a cell-type specific manner.DOMAIN The CTCK domain mediates interchain disulfide bonds with another molecule of MUC5B.DOMAIN The cysteine residues in the Cys-rich subdomain repeats are not involved in disulfide bonding.PTM Highly glycosylated. C-, N- and O-glycosylated. C-mannosylated in the Cys-rich subdomains probably on the first Trp residue of the WXXW motif. Highly O-glycosylated in the Ser/Thr-rich tandem repeat (TR) region. The repeat region is about 59% O-glycosylated with a high abundance of NeuAc(2)Hex(1)HexNac1-ol.DISEASE Disease susceptibility is associated with variants affecting the gene represented in this entry. A common polymorphism in the promoter of MUC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrosis, suggesting that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis (PubMed:21506741).SEQUENCE CAUTION Truncated N-terminus. |
| description | recommendedName: Mucin-5B shortName: MUC-5B alternativeName: Cervical mucin alternativeName: High molecular weight salivary mucin MG1 alternativeName: Mucin-5 subtype B, tracheobronchial alternativeName: Sublingual gland mucin |
| geneName | MUC5B MUC5 |
| identifier | Q9HC84 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Copper Direct protein sequencing Disulfide bond Glycoprotein Metal-binding Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MUC5B |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994968] ENSEMBL:ENSG00000117983 MUC5B [Homo sapiens] |
| secondaryIdentifier | MUC5B_HUMAN O00447 O00573 O14985 O15494 O95291 O95451 Q14881 Q7M4S5 Q99552 Q9UE28 |
| sequenceLength | 5762 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:913676] MUC5B(26-5703) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1462075] Core 5 (MUC5B) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1462102] Core 8 (MUC5B) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1462201] Core 3 (MUC5B) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1462213] T-antigen (MUC5B) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1462242] Core 6 (MUC5B) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1462273] Core 2 (MUC5B) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1462291] Core 4 (MUC5B) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1462327] Core 7 (MUC5B) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1463435] GalNAc-MUC5B(26-5703) [Golgi lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:913609] O-(N-acetylamino)galactosyl-L-threonine at unknown position [ModifiedResidue:913648] O-(N-acetylamino)galactosyl-L-serine at unknown position [GroupModifiedResidue:1462096] O-(N-acetylamino)galactosyl-L-serine (GlcNAc-beta1,3(GlcNAc-beta1,6)GalNac-alpha group) at unknown position [GroupModifiedResidue:1462117] O-(N-acetylamino)galactosyl-L-serine (Gal-alpha1,3-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462135] O-(N-acetylamino)galactosyl-L-serine (GalNAc-alpha1,6-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462228] O-(N-acetylamino)galactosyl-L-serine (GlcNAc-alpha1,3-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462261] O-(N-acetylamino)galactosyl-L-serine (GlcNAc-beta1,3-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462276] O-(N-acetylamino)galactosyl-L-serine (beta-D-Galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl group) at unknown position [GroupModifiedResidue:1462286] O-(N-acetylamino)galactosyl-L-serine (GlcNAc-beta1,6-GalNAc-alpha group) at unknown position [GroupModifiedResidue:1462288] O-(N-acetylamino)galactosyl-L-serine (Gal-beta1,3(GlcNAc-beta1,6)GalNAc-alpha group) at unknown position |
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No pathways have been reviewed or authored by UniProt:Q9HC84 MUC5B (59699)
