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Details on Person UniProt:P55157 MTTP
| Class:Id | ReferenceGeneProduct:59673 |
|---|---|
| _chainChangeLog | signal peptide:1-18 added on Fri February 6 2015;chain:19-894 added on Fri February 6 2015 |
| _displayName | UniProt:P55157 MTTP |
| _timestamp | 2024-11-03 20:10:54 |
| chain | signal peptide:1-18 chain:19-894 |
| checksum | B20260C136BDAB9F |
| comment | FUNCTION Catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between phospholipid surfaces (PubMed:15897609, PubMed:16478722, PubMed:22236406, PubMed:23475612, PubMed:25108285, PubMed:26224785, PubMed:8876250, PubMed:8939939). Required for the assembly and secretion of plasma lipoproteins that contain apolipoprotein B (PubMed:16478722, PubMed:23475612, PubMed:26224785, PubMed:8876250, PubMed:8939939). May be involved in regulating cholesteryl ester biosynthesis in cells that produce lipoproteins (By similarity).CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)CATALYTIC ACTIVITY a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)CATALYTIC ACTIVITY a cholesterol ester(in) = a cholesterol ester(out)CATALYTIC ACTIVITY a triacyl-sn-glycerol(in) = a triacyl-sn-glycerol(out)SUBUNIT Heterodimer; heterodimerizes with the protein disulfide isomerase (P4HB/PDI) (PubMed:16478722, PubMed:23475612, PubMed:25108285, PubMed:26224785). Interacts with APOB (PubMed:25108285, PubMed:26224785, PubMed:27206948). Interacts with PRAP1 (By similarity).INTERACTION Colocalizes with P4HB/PDI in the endoplasmic reticulum (PubMed:23475612, PubMed:26224785).ALTERNATIVE PRODUCTS Liver and small intestine. Also found in ovary, testis and kidney.INDUCTION Positively regulated by cholesterol and negatively regulated by insulin.DISEASE The disease is caused by variants affecting the gene represented in this entry. |
| description | recommendedName: Microsomal triglyceride transfer protein large subunit |
| geneName | MTTP MTP |
| identifier | P55157 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Disease variant Disulfide bond Endoplasmic reticulum Golgi apparatus Lipid transport Lipid-binding Proteomics identification Reference proteome Signal Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MTTP |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8998451] ENSEMBL:ENSG00000138823 MTTP [Homo sapiens] |
| secondaryIdentifier | MTP_HUMAN A8K428 Q08AM4 Q6P5T3 |
| sequenceLength | 894 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8975652] UniProt:P55157-1 MTTP [Homo sapiens] [ReferenceIsoform:8975653] UniProt:P55157-2 MTTP [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:174688] MTTP [endoplasmic reticulum lumen] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P55157 MTTP (59673)
