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Details on Person UniProt:Q9BTC8 MTA3
| Class:Id | ReferenceGeneProduct:59641 |
|---|---|
| _chainChangeLog | chain:1-594 added on Sat February 7 2015 |
| _displayName | UniProt:Q9BTC8 MTA3 |
| _timestamp | 2025-08-15 21:39:31 |
| chain | chain:1-594 |
| checksum | E773603F65A16DF1 |
| comment | FUNCTION Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:12705869, PubMed:16428440, PubMed:28977666). Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels (PubMed:12705869). Contributes to transcriptional repression by BCL6 (PubMed:15454082).SUBUNIT Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:12705869, PubMed:15454082, PubMed:16428440, PubMed:28977666, PubMed:33283408). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:28977666). Interacts with BCL6 (PubMed:15454082). Interacts with NACC2 (PubMed:22926524). Interacts with PWWP2B (By similarity).INTERACTION Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells.INDUCTION By estrogen.SIMILARITY Belongs to the metastasis-associated protein family. |
| description | recommendedName: Metastasis-associated protein MTA3 |
| geneName | MTA3 KIAA1266 |
| identifier | Q9BTC8 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cytoplasm DNA-binding Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Zinc Zinc-finger |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MTA3 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994352] ENSEMBL:ENSG00000057935 MTA3 [Homo sapiens] |
| secondaryIdentifier | MTA3_HUMAN Q9NSP2 Q9ULF4 |
| sequenceLength | 594 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:150633] UniProt:Q9BTC8-2 MTA3 [Homo sapiens] [ReferenceIsoform:413399] UniProt:Q9BTC8-1 MTA3 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:4657013] MTA3 [nucleoplasm] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:Q9BTC8 MTA3 (59641)
