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Details on Person UniProt:Q13330 MTA1

Class:Id	ReferenceGeneProduct:59637
_chainChangeLog	chain:1-715 added on Fri February 6 2015
_displayName	UniProt:Q13330 MTA1
_timestamp	2025-08-15 21:39:30
chain	chain:1-715
checksum	2D5330F0489AE62E
comment	FUNCTION Transcriptional coregulator which can act as both a transcriptional corepressor and coactivator (PubMed:16617102, PubMed:17671180, PubMed:17922032, PubMed:21965678, PubMed:24413532). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). In the NuRD complex, regulates transcription of its targets by modifying the acetylation status of the target chromatin and cofactor accessibility to the target DNA (PubMed:17671180). In conjunction with other components of NuRD, acts as a transcriptional corepressor of BRCA1, ESR1, TFF1 and CDKN1A (PubMed:17922032, PubMed:24413532). Acts as a transcriptional coactivator of BCAS3, and SUMO2, independent of the NuRD complex (PubMed:16617102, PubMed:17671180, PubMed:21965678). Stimulates the expression of WNT1 by inhibiting the expression of its transcriptional corepressor SIX3 (By similarity). Regulates p53-dependent and -independent DNA repair processes following genotoxic stress (PubMed:19837670). Regulates the stability and function of p53/TP53 by inhibiting its ubiquitination by COP1 and MDM2 thereby regulating the p53-dependent DNA repair (PubMed:19837670). Plays a role in the regulation of the circadian clock and is essential for the generation and maintenance of circadian rhythms under constant light and for normal entrainment of behavior to light-dark (LD) cycles (By similarity). Positively regulates the CLOCK-BMAL1 heterodimer mediated transcriptional activation of its own transcription and the transcription of CRY1 (By similarity). Regulates deacetylation of BMAL1 by regulating SIRT1 expression, resulting in derepressing CRY1-mediated transcription repression (By similarity). With TFCP2L1, promotes establishment and maintenance of pluripotency in embryonic stem cells (ESCs) and inhibits endoderm differentiation (By similarity).FUNCTION Binds to ESR1 and sequesters it in the cytoplasm and enhances its non-genomic responses.SUBUNIT Component of the nucleosome remodeling and deacetylase (NuRD) repressor complex, composed of core proteins MTA1, MTA2, MTA3, RBBP4, RBBP7, HDAC1, HDAC2, MBD2, MBD3, and peripherally associated proteins CDK2AP1, CDK2AP2, GATAD2A, GATAD2B, CHD3, CHD4 and CHD5 (PubMed:16428440, PubMed:28977666, PubMed:33283408, PubMed:9885572). The exact stoichiometry of the NuRD complex is unknown, and some subunits such as MBD2 and MBD3, GATAD2A and GATAD2B, and CHD3, CHD4 and CHD5 define mutually exclusive NuRD complexes (PubMed:16428440, PubMed:28977666, PubMed:33283408). Interacts with RBBP4; the interaction is direct (PubMed:24920672). Interacts with BMAL1 (By similarity). Interacts with CLOCK (By similarity). Interacts with COP1 (PubMed:19805145). Interacts with CSNK1G2 in the cytoplasm (PubMed:15077195). Interacts with EP300 (PubMed:16617102). Interacts with HDAC2 (PubMed:17671180, PubMed:19805145, PubMed:21965678, PubMed:24970816). Interacts with IFI16 (PubMed:24413532). Interacts with ITGB3BP/CENPR (PubMed:15254226). Interacts with MBD3L2 (PubMed:15701600). Interacts with MDM2 (PubMed:19837670). Interacts with NACC2 (PubMed:22926524). Interacts with p53/TP53 (PubMed:19837670). Interacts with PIAS1 (PubMed:21965678). Interacts with PIAS3 (PubMed:21965678). Interacts with PIAS4 (PubMed:21965678). Interacts with PWWP2A (PubMed:30327463). Interacts with PWWP2B (By similarity). Interacts with SENP1 (PubMed:21965678). Interacts with SENP2 (PubMed:21965678). Interacts with SIX3; facilitates the binding of SIX3 to the core DNA motif of SIX3 promoter (PubMed:20682799). Interacts with SUMO1 (PubMed:21965678). Interacts with SUMO2 (PubMed:21965678). Interacts with TFCP2L1; which is indispensable for TFCP2L1-mediated self-renewal-promoting effect and endoderm-inhibiting action (By similarity). Interacts with TFAP2C (PubMed:24413532). Interacts with TPR (PubMed:24970816). Interacts with UBE2I/UBC9 (PubMed:21965678).INTERACTION Associated with microtubules (PubMed:24970816). Localization at the nuclear envelope is TPR-dependent (PubMed:24970816).ALTERNATIVE PRODUCTS Widely expressed. High expression in brain, liver, kidney, and cardiac muscle, ovaries, adrenal glands and virgin mammary glands. Higher in tumors than in adjacent normal tissue from the same individual. Up-regulated in a wide variety of cancers including breast, liver, ovarian, and colorectal cancer and its expression levels are closely correlated with tumor aggressiveness and metastasis.DEVELOPMENTAL STAGE Highly expressed in metastatic cells.DOMAIN Isoform Short contains a Leu-Arg-Ile-Leu-Leu motif (ER binding motif).PTM Phosphorylation by CSNK1G2/CK1 triggered by estrogen enhances corepression of estrogen receptor (ER).PTM Acetylation is essential for its transcriptional coactivator activity.PTM Sumoylation positively regulates its transcriptional corepressor activity but does not affect the protein stability. Sumoylated preferentially by SUMO2 or SUMO3 than SUMO1. Sumoylation is enhanced by PIAS1/3/4 and preferentially sumoylated by SUMO2 in the presence of PIAS1/3/4. Desumoylated by SENP1.PTM Ubiquitinated by COP1, which leads to proteasomal degradation.DISEASE Involved in the epigenetic regulation of ESR1 expression in breast cancer in a TFAP2C, IFI16 and HDAC4/5/6-dependent manner.SIMILARITY Belongs to the metastasis-associated protein family.
description	recommendedName: Metastasis-associated protein MTA1
geneName	MTA1
identifier	Q13330
isSequenceChanged	FALSE
keyword	3D-structure Acetylation Activator Alternative splicing Biological rhythms Cytoplasm Cytoskeleton DNA-binding Isopeptide bond Metal-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Repressor Transcription Transcription regulation Ubl conjugation Zinc Zinc-finger
modified	[InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15
name	MTA1
referenceDatabase	[ReferenceDatabase:2] UniProt
referenceGene	[ReferenceDNASequence:8991404] ENSEMBL:ENSG00000182979 MTA1 [Homo sapiens]
secondaryIdentifier	MTA1_HUMAN A5PLK4 Q86SW2 Q8NFI8 Q96GI8
sequenceLength	715
species	[Species:48887] Homo sapiens
(isoformParent)	[ReferenceIsoform:150631] UniProt:Q13330-2 MTA1 [Homo sapiens] [ReferenceIsoform:405594] UniProt:Q13330-1 MTA1 [Homo sapiens] [ReferenceIsoform:8967080] UniProt:Q13330-3 MTA1 [Homo sapiens]
(referenceEntity)	[EntityWithAccessionedSequence:3465537] polySUMO2,3-K509-MTA1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3465550] MTA1 [nucleoplasm] [Homo sapiens]
(referenceSequence)	[GroupModifiedResidue:3465540] sumoylated lysine (polySUMO2,3 [nucleoplasm]) at 509
(secondReferenceSequence)	[InterChainCrosslinkedResidue:3730743] Inter-chain Crosslink via sumoylated lysine at 97 and 509
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No pathways have been reviewed or authored by UniProt:Q13330 MTA1 (59637)