Query author contributions in Reactome
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Details on Person UniProt:P80297 MT1X
| Class:Id | ReferenceGeneProduct:59627 |
|---|---|
| _chainChangeLog | chain:1-61 added on Fri February 6 2015 |
| _displayName | UniProt:P80297 MT1X |
| _timestamp | 2024-11-03 19:52:40 |
| chain | chain:1-61 |
| checksum | 381966F942E986B2 |
| comment | FUNCTION Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids. May be involved in FAM168A anti-apoptotic signaling (PubMed:23251525).SUBUNIT Monomer. Interacts with FAM168A (PubMed:23251525).INTERACTION Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines.SIMILARITY Belongs to the metallothionein superfamily. Type 1 family. |
| description | recommendedName: Metallothionein-1X shortName: MT-1X alternativeName: Metallothionein-IX shortName: MT-IX |
| geneName | MT1X |
| identifier | P80297 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Cadmium Copper Direct protein sequencing Metal-binding Metal-thiolate cluster Phosphoprotein Proteomics identification Reference proteome Zinc |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MT1X |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5660071] ENSEMBL:ENSG00000187193 MT1X [Homo sapiens] |
| secondaryIdentifier | MT1X_HUMAN A8MUC7 |
| sequenceLength | 61 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5660400] MT1X [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:8958308] MT1X [extracellular region] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P80297 MT1X (59627)
