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Details on Person UniProt:Q9UEW3 MARCO
| Class:Id | ReferenceGeneProduct:59547 |
|---|---|
| _chainChangeLog | chain:1-520 added on Fri February 6 2015 |
| _displayName | UniProt:Q9UEW3 MARCO |
| _timestamp | 2024-11-03 20:15:16 |
| chain | chain:1-520 |
| checksum | 8CFC5F6F99EEBA8D |
| comment | FUNCTION Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).SUBUNIT Homotrimer; disulfide-linked. Trimers may assemble in larger oligomers thus resulting in the creation of a large surface capable of interacting with very large ligands.SUBCELLULAR LOCATION Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen (PubMed:9468508).PTM N-glycosylated. |
| description | recommendedName: Macrophage receptor MARCO alternativeName: Macrophage receptor with collagenous structure alternativeName: Scavenger receptor class A member 2 |
| geneName | MARCO SCARA2 |
| identifier | Q9UEW3 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Cell membrane Collagen Disulfide bond Glycoprotein Immunity Innate immunity Membrane Proteomics identification Receptor Reference proteome Signal-anchor Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MARCO |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8999609] ENSEMBL:ENSG00000019169 MARCO [Homo sapiens] |
| secondaryIdentifier | MARCO_HUMAN B4DW79 Q9Y5S3 |
| sequenceLength | 520 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8968374] UniProt:Q9UEW3-1 MARCO [Homo sapiens] [ReferenceIsoform:8968375] UniProt:Q9UEW3-2 MARCO [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:2173724] 6xHC-MARCO [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:2239463] 6xHC-MARCO [endocytic vesicle membrane] [Homo sapiens] |
| (referenceSequence) | [IntraChainCrosslinkedResidue:2173713] Intra-chain Crosslink via L-cystine (cross-link) at 460 and 518 [IntraChainCrosslinkedResidue:2173722] Intra-chain Crosslink via L-cystine (cross-link) at 488 and 498 [IntraChainCrosslinkedResidue:2173750] Intra-chain Crosslink via L-cystine (cross-link) at 447 and 508 |
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No pathways have been reviewed or authored by UniProt:Q9UEW3 MARCO (59547)
