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Details on Person UniProt:P20645 M6PR
| Class:Id | ReferenceGeneProduct:59537 |
|---|---|
| _chainChangeLog | signal peptide:1-26 added on Fri February 6 2015;chain:27-277 added on Fri February 6 2015 |
| _displayName | UniProt:P20645 M6PR |
| _timestamp | 2024-11-03 19:41:57 |
| chain | signal peptide:1-26 chain:27-277 |
| checksum | 1093FE25DEB6C8E8 |
| comment | FUNCTION Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.SUBUNIT Homodimer. Binds GGA1, GGA2 and GGA3.INTERACTION The extracellular domain is homologous to the repeating units (of approximately 147 AA) of the cation-independent mannose 6-phosphate receptor.MISCELLANEOUS This receptor has optimal binding in the presence of divalent cations. |
| description | recommendedName: Cation-dependent mannose-6-phosphate receptor shortName: CD Man-6-P receptor shortName: CD-MPR alternativeName: 46 kDa mannose 6-phosphate receptor shortName: MPR 46 |
| geneName | M6PR MPR46 MPRD |
| identifier | P20645 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Disulfide bond Glycoprotein Lysosome Membrane Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transmembrane Transmembrane helix Transport |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | M6PR |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994346] ENSEMBL:ENSG00000003056 M6PR [Homo sapiens] |
| secondaryIdentifier | MPRD_HUMAN A8K528 D3DUV5 |
| sequenceLength | 277 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:429824] M6PR [Golgi membrane] [Homo sapiens] [EntityWithAccessionedSequence:432696] M6PR [lysosomal membrane] [Homo sapiens] [EntityWithAccessionedSequence:6814611] M6PR [trans-Golgi network membrane] [Homo sapiens] [EntityWithAccessionedSequence:6814613] M6PR [transport vesicle] [Homo sapiens] [EntityWithAccessionedSequence:8864564] M6PR [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:8869100] M6PR [clathrin-coated endocytic vesicle membrane] [Homo sapiens] [EntityWithAccessionedSequence:9958398] M6PR [late endosome membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P20645 M6PR (59537)
