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Details on Person UniProt:P36507 MAP2K2
| Class:Id | ReferenceGeneProduct:59505 |
|---|---|
| _chainChangeLog | chain:1-400 added on Sat February 7 2015 |
| _displayName | UniProt:P36507 MAP2K2 |
| _timestamp | 2025-02-21 19:50:15 |
| chain | chain:1-400 |
| checksum | 3401D522515C30A5 |
| comment | FUNCTION Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases (By similarity). Activates BRAF in a KSR1 or KSR2-dependent manner; by binding to KSR1 or KSR2 releases the inhibitory intramolecular interaction between KSR1 or KSR2 protein kinase and N-terminal domains which promotes KSR1 or KSR2-BRAF dimerization and BRAF activation (PubMed:29433126).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)COFACTOR Interacts with MORG1 (By similarity). Interacts with SGK1 (PubMed:19447520). Interacts with KSR1 (PubMed:10409742). Interacts with KSR1 and BRAF; the interaction with KSR1 mediates KSR1-BRAF dimerization (PubMed:29433126). Interacts with GLS (PubMed:22538822).INTERACTION Membrane localization is probably regulated by its interaction with KSR1.PTM MAPKK is itself dependent on Ser/Thr phosphorylation for activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1). Phosphorylated by MAP2K1/MEK1 (By similarity).PTM (Microbial infection) Acetylation of Ser-222 and Ser-226 by Yersinia YopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. |
| description | recommendedName: Dual specificity mitogen-activated protein kinase kinase 2 shortName: MAP kinase kinase 2 shortName: MAPKK 2 ecNumber evidence="7"2.7.12.2 alternativeName: ERK activator kinase 2 alternativeName: MAPK/ERK kinase 2 shortName: MEK 2 |
| geneName | MAP2K2 MEK2 MKK2 PRKMK2 |
| identifier | P36507 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation ATP-binding Cardiomyopathy Cytoplasm Direct protein sequencing Disease variant Ectodermal dysplasia Intellectual disability Kinase Magnesium Membrane Metal-binding Nucleotide-binding Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Tyrosine-protein kinase |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MAP2K2 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996719] ENSEMBL:ENSG00000126934 MAP2K2 [Homo sapiens] |
| secondaryIdentifier | MP2K2_HUMAN |
| sequenceLength | 400 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:59504] MAP2K2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:109848] p-S,T-MAP2K2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:169292] p-S222,S226-MAP2K2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:197543] p-2T-MAP2K2 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5211334] MAP2K2(1-10) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5211337] MAP2K2(11-400) [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:6802550] p-S222,S226-MAP2K2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:9652070] MAP2K2 C125S [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9652073] MAP2K2 F57C [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:9652076] MAP2K2 L46F [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:109846] O-phospho-L-serine at unknown position [ModifiedResidue:109847] O-phospho-L-threonine at unknown position [ModifiedResidue:169288] O-phospho-L-serine at 222 [ModifiedResidue:169290] O-phospho-L-serine at 226 [ModifiedResidue:197547] O-phospho-L-threonine at unknown position [ReplacedResidue:9651856] L-asparagine 126 replaced with L-aspartic acid [ReplacedResidue:9651861] L-cysteine 125 replaced with L-serine [ReplacedResidue:9651869] L-leucine 46 replaced with L-phenylalanine [ReplacedResidue:9651886] L-phenylalanine 57 replaced with L-cysteine [ReplacedResidue:9651893] L-proline 128 replaced with L-glutamine |
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No pathways have been reviewed or authored by UniProt:P36507 MAP2K2 (59505)
