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Details on Person UniProt:P50281 MMP14
| Class:Id | ReferenceGeneProduct:59405 |
|---|---|
| _chainChangeLog | signal peptide:1-20 added on Sat February 7 2015;propeptide:21-111 added on Sat February 7 2015;chain:112-582 added on Sat February 7 2015 |
| _displayName | UniProt:P50281 MMP14 |
| _timestamp | 2024-11-03 19:41:56 |
| chain | signal peptide:1-20 propeptide:21-111 chain:112-582 |
| checksum | 3722DE286A4BBCDE |
| comment | FUNCTION Endopeptidase that degrades various components of the extracellular matrix such as collagen (PubMed:8015608). Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). Activates progelatinase A/MMP2, thereby acting as a positive regulator of cell growth and migration (PubMed:22065321, PubMed:8015608). Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657, PubMed:22065321). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a regulator of Notch signaling by mediating cleavage and inhibition of DLL1 (PubMed:21572390). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). Acts as a negative regulator of the GDF15-GFRAL aversive response by mediating cleavage and inactivation of GFRAL (PubMed:35177851).CATALYTIC ACTIVITY Endopeptidase activity. Activates progelatinase A by cleavage of the propeptide at 37-Asn-|-Leu-38. Other bonds hydrolyzed include 35-Gly-|-Ile-36 in the propeptide of collagenase 3, and 341-Asn-|-Phe-342, 441-Asp-|-Leu-442 and 354-Gln-|-Thr-355 in the aggrecan interglobular domain.COFACTOR Binds 1 zinc ion per subunit.COFACTOR Interacts (via C-terminal cytoplasmic tail) with BST2.INTERACTION Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Forms a complex with BST2 and localizes to the cytoplasm (PubMed:17081065).TISSUE SPECIFICITY Expressed in stromal cells of colon, breast, and head and neck. Expressed in lung tumors.INDUCTION Up-regulated by NANOS1.DOMAIN The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.PTM The precursor is cleaved by a furin endopeptidase.PTM Tyrosine phosphorylated by PKDCC/VLK.DISEASE The disease is caused by variants affecting the gene represented in this entry.SIMILARITY Belongs to the peptidase M10A family. |
| description | recommendedName: Matrix metalloproteinase-14 shortName: MMP-14 ecNumber evidence="18 22"3.4.24.80 alternativeName: MMP-X1 alternativeName: Membrane-type matrix metalloproteinase 1 shortName: MT-MMP 1 shortName: MTMMP1 alternativeName: fullName evidence="27"Membrane-type-1 matrix metalloproteinase shortName evidence="27"MT1-MMP shortName evidence="27"MT1MMP |
| geneName | MMP14 |
| identifier | P50281 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Calcium Cell membrane Cleavage on pair of basic residues Cytoplasm Direct protein sequencing Disease variant Disulfide bond Hydrolase Membrane Metal-binding Metalloprotease Osteoporosis Phosphoprotein Protease Proteomics identification Reference proteome Repeat Signal Transmembrane Transmembrane helix Zinc Zymogen |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9917590] Weiser, Joel, 2024-08-09 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MMP14 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8990254] ENSEMBL:ENSG00000157227 MMP14 [Homo sapiens] |
| secondaryIdentifier | MMP14_HUMAN A8K5L0 Q6GSF3 Q92678 |
| sequenceLength | 582 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:1442472] MMP14 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1604689] MMP14(21-582) [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:1604724] MMP14 [Golgi lumen] [Homo sapiens] [EntityWithAccessionedSequence:9858808] MMP14 [Golgi membrane] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P50281 MMP14 (59405)
