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Details on Person UniProt:P24844 MYL9
| Class:Id | ReferenceGeneProduct:59377 |
|---|---|
| _chainChangeLog | initiator methionine:1 added on Fri February 6 2015;chain:2-172 added on Fri February 6 2015;initiator methionine:1 for 59377 removed on Fri Nov 03 2023;initiator methionine: for 59377 added on Fri Nov 03 2023;initiator methionine: for 59377 removed on Fri Aug 15 2025;initiator methionine:1 for 59377 added on Fri Aug 15 2025 |
| _displayName | UniProt:P24844 MYL9 |
| _timestamp | 2025-08-15 21:24:32 |
| chain | initiator methionine:1 chain:2-172 |
| checksum | 4C9839E85154CDA8 |
| comment | FUNCTION Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity via its phosphorylation. Implicated in cytokinesis, receptor capping, and cell locomotion (PubMed:11942626, PubMed:2526655). In myoblasts, may regulate PIEZO1-dependent cortical actomyosin assembly involved in myotube formation (By similarity).SUBUNIT Myosin is a hexamer of 2 heavy chains and 4 light chains: interacts with myosin heavy chain MYO19 (By similarity). Interacts with LUZP1; the interaction results in inhibition of phosphorylation of MYL9 by DAPK3 (PubMed:38009294).INTERACTION Colocalizes with F-actin, MYH9 and PIEZO1 at the actomyosin cortex in myoblasts.ALTERNATIVE PRODUCTS Smooth muscle tissues and in some, but not all, nonmuscle cells.PTM Phosphorylation increases the actin-activated myosin ATPase activity and thereby regulates the contractile activity. It is required to generate the driving force in the migration of the cells but not necessary for localization of myosin-2 at the leading edge. Phosphorylation is required for myotube formation. Phosphorylated by DAPK3; DAPK3-mediated phosphorylation is inhibited by LUZP1 (PubMed:38009294).DISEASE The disease may be caused by variants affecting the gene represented in this entry.MISCELLANEOUS This chain binds calcium. |
| description | recommendedName: Myosin regulatory light polypeptide 9 alternativeName: 20 kDa myosin light chain shortName: LC20 alternativeName: MLC-2C alternativeName: Myosin RLC alternativeName: Myosin regulatory light chain 2, smooth muscle isoform alternativeName: Myosin regulatory light chain 9 alternativeName: Myosin regulatory light chain MRLC1 |
| geneName | MYL9 MLC2 MRLC1 MYRL2 |
| identifier | P24844 |
| isSequenceChanged | FALSE |
| keyword | Acetylation Alternative splicing Calcium Cytoplasm Cytoskeleton Metal-binding Motor protein Muscle protein Myosin Phosphoprotein Proteomics identification Reference proteome Repeat |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MYL9 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8938197] ENSEMBL:ENSG00000101335 MYL9 [Homo sapiens] |
| secondaryIdentifier | MYL9_HUMAN E1P5T6 Q9BQL9 Q9BUF9 Q9H136 |
| sequenceLength | 172 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8973359] UniProt:P24844-1 MYL9 [Homo sapiens] [ReferenceIsoform:8973360] UniProt:P24844-2 MYL9 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:390752] p-T19,S20-MYL9 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:390753] MYL9 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:445798] p-S20-MYL9 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5668927] p-T19-MYL9 [cytosol] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:390743] O-phospho-L-serine at 20 [ModifiedResidue:390747] O-phospho-L-threonine at 19 |
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No pathways have been reviewed or authored by UniProt:P24844 MYL9 (59377)
