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Details on Person UniProt:Q16659 MAPK6
| Class:Id | ReferenceGeneProduct:59289 |
|---|---|
| _chainChangeLog | chain:1-721 added on Sat February 7 2015 |
| _displayName | UniProt:Q16659 MAPK6 |
| _timestamp | 2025-08-15 22:17:47 |
| chain | chain:1-721 |
| checksum | DAA3AAA9B98BB31F |
| comment | FUNCTION Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)COFACTOR Activated by phosphorylation at Ser-189.SUBUNIT Heterodimer with ERK4/MAPK4. Interacts with (via FRIEDE motif) MAPKAPK5 (By similarity). Interacts with UBE3A; this interaction may be indirect and mediated by HERC2, possibly via HERC2 interaction with NEURL4.INTERACTION Translocates to the cytoplasm following interaction with MAPKAPK5.TISSUE SPECIFICITY Highest expression in the skeletal muscle, followed by the brain. Also found in heart, placenta, lung, liver, pancreas, kidney and skin fibroblasts.DOMAIN In contrast to classical MAPKs, the TXY motif within the activation loop is replaced by the SEG motif, whose phosphorylation activates the MAP kinases.PTM Phosphorylated at Ser-189 by PAK1, PAK2 and PAK3 resulting in catalytic activation. Phosphorylated by MAPKAPK5 at other sites.PTM Ubiquitination at Met-1 leads to degradation by the proteasome pathway.SIMILARITY Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. |
| description | recommendedName: Mitogen-activated protein kinase 6 shortName: MAP kinase 6 shortName: MAPK 6 ecNumber: 2.7.11.24 alternativeName: Extracellular signal-regulated kinase 3 shortName: ERK-3 alternativeName: MAP kinase isoform p97 shortName: p97-MAPK |
| geneName | MAPK6 ERK3 PRKM6 |
| identifier | Q16659 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell cycle Cytoplasm Kinase Nucleotide-binding Nucleus Phosphoprotein Proteomics identification Reference proteome Serine/threonine-protein kinase Transferase Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | MAPK6 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:5692684] ENSEMBL:ENSG00000069956 MAPK6 [Homo sapiens] |
| secondaryIdentifier | MK06_HUMAN B2R945 B5BU65 Q68DH4 Q8IYN8 |
| sequenceLength | 721 |
| species | [Species:48887] Homo sapiens |
| (referenceEntity) | [EntityWithAccessionedSequence:5686979] MAPK6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5687000] ub-MAPK6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5687015] p-S189 MAPK6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5687019] p-S189 MAPK6 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:5692665] p-3S,T MAPK6 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:5692686] MAPK6 [nucleoplasm] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:5687017] O-phospho-L-serine at 189 [GroupModifiedResidue:5687369] modified L-methionine residue (K48polyUb [cytosol]) at 1 [ModifiedResidue:5692664] O-phospho-L-serine at 705 [ModifiedResidue:5692666] O-phospho-L-serine at 684 [ModifiedResidue:5692667] O-phospho-L-threonine at 698 [ModifiedResidue:5692669] O-phospho-L-serine at 688 |
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No pathways have been reviewed or authored by UniProt:Q16659 MAPK6 (59289)
