Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:O00222 GRM8
| Class:Id | ReferenceGeneProduct:59245 |
|---|---|
| _chainChangeLog | signal peptide:1-33 added on Fri February 6 2015;chain:34-908 added on Fri February 6 2015 |
| _displayName | UniProt:O00222 GRM8 |
| _timestamp | 2024-11-03 19:56:33 |
| chain | signal peptide:1-33 chain:34-908 |
| checksum | 95C2D5883DAF6FDE |
| comment | FUNCTION G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.SUBUNIT Interacts with PICK1.SUBCELLULAR LOCATION Belongs to the G-protein coupled receptor 3 family. |
| description | recommendedName: Metabotropic glutamate receptor 8 shortName: mGluR8 |
| geneName | GRM8 GPRC1H MGLUR8 |
| identifier | O00222 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Alternative splicing Cell membrane Disulfide bond G-protein coupled receptor Glycoprotein Isopeptide bond Membrane Proteomics identification Receptor Reference proteome Sensory transduction Signal Transducer Transmembrane Transmembrane helix Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | GRM8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8996604] ENSEMBL:ENSG00000179603 GRM8 [Homo sapiens] |
| secondaryIdentifier | GRM8_HUMAN A4D0Y3 B0FZ74 B0M0L0 O15493 O95945 O95946 Q3MIV9 Q52M02 Q6J165 |
| sequenceLength | 908 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:150294] UniProt:O00222-2 GRM8 [Homo sapiens] [ReferenceIsoform:150295] UniProt:O00222-3 GRM8 [Homo sapiens] [ReferenceIsoform:401094] UniProt:O00222-1 GRM8 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:420567] GRM8 [plasma membrane] [Homo sapiens] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:O00222 GRM8 (59245)
