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Details on Person UniProt:Q08431 MFGE8
| Class:Id | ReferenceGeneProduct:59185 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Sat February 7 2015;chain:24-387 added on Sat February 7 2015;chain:202-387 added on Sat February 7 2015;chain:268-317 added on Sat February 7 2015 |
| _displayName | UniProt:Q08431 MFGE8 |
| _timestamp | 2024-11-03 20:01:49 |
| chain | signal peptide:1-23 chain:24-387 chain:202-387 chain:268-317 |
| checksum | 9EA357581933789D |
| comment | FUNCTION Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.FUNCTION Main constituent of aortic medial amyloid.SUBCELLULAR LOCATION Located in the acrosomal region of zona-pellucida bound sperm.ALTERNATIVE PRODUCTS Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas.DOMAIN The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes.PTM Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273.MISCELLANEOUS It is unsure whether Met-1 or an upstream Met is the initiator as the upstream Met corresponds to polymorphism rs1879326. |
| description | recommendedName: Lactadherin alternativeName: Breast epithelial antigen BA46 alternativeName: HMFG alternativeName: MFGM alternativeName: Milk fat globule-EGF factor 8 shortName: MFG-E8 alternativeName: SED1 component recommendedName: Lactadherin short form /component component recommendedName: Medin /component |
| geneName | MFGE8 |
| identifier | Q08431 |
| isSequenceChanged | FALSE |
| keyword | Alternative splicing Amyloid Angiogenesis Cell adhesion Cytoplasmic vesicle Direct protein sequencing Disulfide bond EGF-like domain Fertilization Glycoprotein Membrane Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 |
| name | MFGE8 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8989626] ENSEMBL:ENSG00000140545 MFGE8 [Homo sapiens] |
| secondaryIdentifier | MFGM_HUMAN B2R6M7 F5GZN3 Q53FU9 Q7Z3D2 Q9BTL9 |
| sequenceLength | 387 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8966166] UniProt:Q08431-1 MFGE8 [Homo sapiens] [ReferenceIsoform:8966167] UniProt:Q08431-2 MFGE8 [Homo sapiens] [ReferenceIsoform:8966168] UniProt:Q08431-3 MFGE8 [Homo sapiens] [ReferenceIsoform:9627842] UniProt:Q08431-4 MFGE8 [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:508401] MFGE8(24-387) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:976952] MFGE8(268-317) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:1297291] MFGE8(24-387) [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:1297301] MFGE8(24-387) [extracellular region] [Homo sapiens] [EntityWithAccessionedSequence:8956715] MFGE8 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:8957017] p-MFGE8 [endoplasmic reticulum lumen] [Homo sapiens] [EntityWithAccessionedSequence:9962443] MFGE8 [secretory granule lumen] [Homo sapiens] |
| (referenceSequence) | [ModifiedResidue:8956984] phosphorylated residue at unknown position |
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No pathways have been reviewed or authored by UniProt:Q08431 MFGE8 (59185)
