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Details on Person UniProt:P31153 MAT2A
| Class:Id | ReferenceGeneProduct:59169 |
|---|---|
| _chainChangeLog | chain:1-395 added on Sat February 7 2015 |
| _displayName | UniProt:P31153 MAT2A |
| _timestamp | 2025-02-21 20:01:06 |
| chain | chain:1-395 |
| checksum | 2E7D1B91CC4F7BDD |
| comment | FUNCTION Catalyzes the formation of S-adenosylmethionine from methionine and ATP. The reaction comprises two steps that are both catalyzed by the same enzyme: formation of S-adenosylmethionine (AdoMet) and triphosphate, and subsequent hydrolysis of the triphosphate.CATALYTIC ACTIVITY L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphateCOFACTOR Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.COFACTOR Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.PATHWAY Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.SUBUNIT Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain (PubMed:10644686, PubMed:23189196). Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain (PubMed:25075345).INTERACTION Detected in kidney.MISCELLANEOUS Protein expression is regulated by post-transcriptional regulation: in presence of S-adenosyl-L-methionine, METTL16 binds and methylates the first hairpin of the 3'-UTR region of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:29262316, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, METTL16 binds the 3'-UTR region of MAT2A mRNA without methylating it due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753).SIMILARITY Belongs to the AdoMet synthase family. |
| description | recommendedName: S-adenosylmethionine synthase isoform type-2 shortName: AdoMet synthase 2 ecNumber evidence="2 4 5"2.5.1.6 alternativeName: Methionine adenosyltransferase 2 shortName evidence="10"MAT 2 alternativeName: Methionine adenosyltransferase II shortName: MAT-II |
| geneName | MAT2A AMS2 MATA2 |
| identifier | P31153 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure Acetylation Alternative splicing ATP-binding Isopeptide bond Magnesium Metal-binding Nucleotide-binding One-carbon metabolism Phosphoprotein Potassium Proteomics identification Reference proteome Transferase Ubl conjugation |
| modified | [InstanceEdit:9836292] Weiser, Joel, 2023-05-25 [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9926675] Weiser, Joel, 2024-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 |
| name | MAT2A |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| referenceGene | [ReferenceDNASequence:8994943] ENSEMBL:ENSG00000168906 MAT2A [Homo sapiens] |
| secondaryIdentifier | METK2_HUMAN A8K511 B4DN45 D6W5L1 Q53SP5 |
| sequenceLength | 395 |
| species | [Species:48887] Homo sapiens |
| (isoformParent) | [ReferenceIsoform:8965695] UniProt:P31153-1 MAT2A [Homo sapiens] [ReferenceIsoform:8965696] UniProt:P31153-2 MAT2A [Homo sapiens] |
| (referenceEntity) | [EntityWithAccessionedSequence:174363] MAT2A [cytosol] [Homo sapiens] |
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No pathways have been reviewed or authored by UniProt:P31153 MAT2A (59169)
